F
Francesco Spigonardo
Researcher at University of Rome Tor Vergata
Publications - 10
Citations - 1300
Francesco Spigonardo is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Simvastatin & Myocardial infarction. The author has an hindex of 9, co-authored 10 publications receiving 1243 citations. Previous affiliations of Francesco Spigonardo include University of Chieti-Pescara.
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Journal ArticleDOI
A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.
Francesco Cipollone,Elena Toniato,Stefano Martinotti,Maria Fazia,Annalisa Iezzi,Chiara Cuccurullo,Barbara Pini,Sebastiano Ursi,Gianfranco Vitullo,Maurizio Averna,Marcello Arca,Anna Montali,Filomena Campagna,Sante Ucchino,Francesco Spigonardo,Stefano Taddei,Agostino Virdis,Giovanni Ciabattoni,Alberto Notarbartolo,Franco Cuccurullo,Andrea Mezzetti +20 more
TL;DR: It is found that the -765G-->C polymorphism of the COX-2 gene is associated with a decreased risk of MI and stroke and detection of this genotype may be useful for predicting genetic risk ofMI and stroke.
Journal ArticleDOI
Association Between 5-Lipoxygenase Expression and Plaque Instability in Humans
Francesco Cipollone,Andrea Mezzetti,Maria Fazia,Chiara Cuccurullo,Annalisa Iezzi,Sante Ucchino,Francesco Spigonardo,Marco Bucci,Franco Cuccurullo,Stephen M. Prescott,Diana M. Stafforini +10 more
TL;DR: The expression of 5-LO is elevated in symptomatic compared with asymptomatic plaques and is associated with acute ischemic syndromes, possibly through the generation of LTB4, subsequent MMP biosynthesis, and plaque rupture.
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Suppression of Rage as a Basis of Simvastatin-Dependent Plaque Stabilization in Type 2 Diabetes
Chiara Cuccurullo,Annalisa Iezzi,Maria Fazia,Domenico De Cesare,Andrea Di Francesco,Raffaella Muraro,Roberto Bei,Sante Ucchino,Francesco Spigonardo,Francesco Chiarelli,Ann Marie Schmidt,Franco Cuccurullo,Andrea Mezzetti,Francesco Cipollone +13 more
TL;DR: This study supports the hypothesis that simvastatin inhibits plaque RAGE expression by decreasing MPO-dependent AGE generation, which might contribute to plaque stabilization by inhibiting the biosynthesis of PGE2-dependent MMPs, responsible for plaque rupture.
Journal ArticleDOI
A Unique MicroRNA Signature Associated With Plaque Instability in Humans
Francesco Cipollone,Lara Felicioni,Riccardo Sarzani,Sante Ucchino,Francesco Spigonardo,Claudia Mandolini,Sara Malatesta,Marco Bucci,Chiara Mammarella,Donato Santovito,Federica de Lutiis,Antonio Marchetti,Andrea Mezzetti,Fiamma Buttitta +13 more
TL;DR: It is suggested that miRNAs may have an important role in regulating the evolution of atherosclerotic plaque toward instability and rupture and by identifying the specific miRNA signature for stroke now, the authors are able to use computer algorithms to identify previously unrecognized molecular targets.
Journal ArticleDOI
Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans.
Francesco Cipollone,Maria Fazia,Annalisa Iezzi,Mirco Zucchelli,Barbara Pini,Domenico De Cesare,Sante Ucchino,Francesco Spigonardo,Guido Bajocchi,Roberto Bei,Raffaella Muraro,Luciano Artese,Adriano Piattelli,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +15 more
TL;DR: This study demonstrates that simvastatin decreases inflammation and inhibits COX-2/mPGES expression in plaque macrophages, and this effect in turn may contribute to plaque stabilization by inhibition of MMP-induced plaque rupture.