M
Maria Fazia
Researcher at University of Chieti-Pescara
Publications - 24
Citations - 2870
Maria Fazia is an academic researcher from University of Chieti-Pescara. The author has contributed to research in topics: Inflammation & Restenosis. The author has an hindex of 20, co-authored 24 publications receiving 2776 citations. Previous affiliations of Maria Fazia include University of Rome Tor Vergata.
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Journal ArticleDOI
The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control.
Francesco Cipollone,Annalisa Iezzi,Maria Fazia,Mirco Zucchelli,Barbara Pini,Chiara Cuccurullo,Domenico De Cesare,Giovanni De Blasis,Raffaella Muraro,Roberto Bei,Francesco Chiarelli,Ann Marie Schmidt,Franco Cuccurullo,Andrea Mezzetti +13 more
TL;DR: It is demonstrated in humans that RAGE overexpression is associated with enhanced inflammatory reaction and COX-2/mPGES-1 expression in diabetic plaque macrophages, and this effect may contribute to plaque destabilization by inducing culprit metalloproteinase expression.
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Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.
Francesco Cipollone,Cesaria Prontera,Barbara Pini,Matteo Marini,Maria Fazia,Domenico De Cesare,Annalisa Iezzi,Sante Ucchino,Gianfranco Boccoli,Vittorio Saba,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: This study provides evidence that synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through metalloproteinase-induced plaque rupture.
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A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.
Francesco Cipollone,Elena Toniato,Stefano Martinotti,Maria Fazia,Annalisa Iezzi,Chiara Cuccurullo,Barbara Pini,Sebastiano Ursi,Gianfranco Vitullo,Maurizio Averna,Marcello Arca,Anna Montali,Filomena Campagna,Sante Ucchino,Francesco Spigonardo,Stefano Taddei,Agostino Virdis,Giovanni Ciabattoni,Alberto Notarbartolo,Franco Cuccurullo,Andrea Mezzetti +20 more
TL;DR: It is found that the -765G-->C polymorphism of the COX-2 gene is associated with a decreased risk of MI and stroke and detection of this genotype may be useful for predicting genetic risk ofMI and stroke.
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Elevated Circulating Levels of Monocyte Chemoattractant Protein-1 in Patients With Restenosis After Coronary Angioplasty
Francesco Cipollone,Matteo Marini,Maria Fazia,Barbara Pini,Annalisa Iezzi,Marcella Reale,L. Paloscia,Guido Materazzo,E. D'Annunzio,Pio Conti,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: This study suggests that MCP-1 production and macrophage accumulation in the balloon-injured vessel may play a pivotal role in restenosis after PTCA and may induce luminal renarrowing, at least in part, by inducing O(2)(-) release in monocytes.
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Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy.
Francesco Cipollone,Andrea Mezzetti,Ettore Porreca,Concetta Di Febbo,Michele Nutini,Maria Fazia,Angela Falco,Franco Cuccurullo,Giovanni Davì +8 more
TL;DR: It is suggested that sCD40L may represent the molecular link between hypercholesterolemia and the prothrombotic state and demonstrates that statin therapy may significantly reduce s CD40L and theProthromBotic state.