Francine E. Brennan

TL;DR: Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box.

TL;DR: Surprisingly, SRY expression was detected throughout this entire developmental period in male fetal tissue and in gonads from male pouch young and it was established that in the tammar SRY is expressed from at least 6 days before the appearance of Sertoli cells until long after the immature testis has fully differentiated.

TL;DR: Comparisons of genomic and cDNA sequences are reported that now provide evidence of a de novo insertion of an intron into the SRY gene of dasyurid marsupials, demonstrating that introns may be inserted as spliced units within a developmentally crucial gene without disrupting its function.

TL;DR: The opening summary was inadvertantly omitted and the first page of the letter published in the NOVEMBER issue of Nature Genetics has been printed in its entirety.

TL;DR: There is compelling evidence from mutation analysis and transgenesis that the SPY gene isolated from human3 and mouse4 encodes the testis-determining factor on the mammalian Y chromosome.