Francis G Gabriel

TL;DR: This results indicate that tolerogenic DCs and suppressor T lymphocytes are present in melanoma at all stages of disease progression, and suggest that negative SLN contain immunosuppressive cells and cytokines, due to preconditioning by tolerogenicDCs migrating from the primary melanoma site to the SLN.

TL;DR: It is suggested that up-regulation of resistance genes or down-regulation in target genes may occur rapidly in human solid tumors, within days of the start of treatment, and that similar changes are present in pre- and post-chemotherapy biopsy material.

TL;DR: Genes predicted to be involved in known mechanisms drug sensitivity and resistance correlate well with in vitro chemosensitivity and may allow the definition of predictive signatures to guide individualized chemotherapy in lung cancer.

TL;DR: Intraoperative assessment of SLNs in breast cancer using a molecular assay is a safe, acceptable and accurate technique that allows a reduction in the frequency of delayed axillary clearance surgery.

TL;DR: Data suggest that melanoma chemosensitivity is influenced by known resistance mechanisms, including susceptibility to apoptosis, which may increase understanding of the mechanisms underlying chemos sensitivity to drugs active against melanoma and provide signatures with predictive value.