F
Francis Grand
Publications - 1
Citations - 551
Francis Grand is an academic researcher. The author has contributed to research in topics: Antigen & Human leukocyte antigen. The author has an hindex of 1, co-authored 1 publications receiving 466 citations.
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Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
Brian Cameron,Andrew B. Gerry,Joseph Dukes,Jane Harper,Vivekanandan Kannan,Frayne Bianchi,Francis Grand,Joanna E. Brewer,Minnal Gupta,Gabriela Plesa,Giovanna Bossi,Annelise Vuidepot,Alex Powlesland,Alison Legg,Katherine Adams,Alan D. Bennett,Nicholas J. Pumphrey,Daniel Williams,Gwendolyn Binder-Scholl,Irina Kulikovskaya,Bruce L. Levine,James L. Riley,Angel Varela-Rohena,Edward A. Stadtmauer,Aaron P. Rapoport,Gerald P. Linette,Carl H. June,Namir J. Hassan,Michael Kalos,Bent K. Jakobsen +29 more
TL;DR: A T cell engineered to target one such antigen—MAGE A3—cross-reacts with a peptide from a muscle protein, Titin, which is likely the cause of the off-target toxicity.