F
Francis J. Martin
Researcher at Alza
Publications - 48
Citations - 4458
Francis J. Martin is an academic researcher from Alza. The author has contributed to research in topics: Liposome & Surface coating. The author has an hindex of 23, co-authored 48 publications receiving 4393 citations.
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Patent
Liposome extrusion method
TL;DR: In this article, a suspension of heterogeneous size liposomes is passed through a polymer filter having a web-like construction providing a network of interconnected, tortuous-path capillary pores, and a membrane thickness of at least about 100 microns.
Patent
Lipid-polymer conjugates and liposomes
TL;DR: In this paper, a lipid-polymer conjugate for long-circulating liposomes is presented. But the conjugates do not include a vesicle-forming lipid having convalently attached to its polar head group, such as polyvinylpyrrolidone or polyaspartamide.
Journal ArticleDOI
Doxorubicin Encapsulated in Liposomes Containing Surface-Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS-Related Kaposi's Sarcoma
Donald W. Northfelt,Donald W. Northfelt,Francis J. Martin,Paul A. Volberding,Paul A. Volberding,Julie Russell,Julie Russell,Mary S. Newman,Michael Amantea,Lawrence D. Kaplan,Lawrence D. Kaplan +10 more
TL;DR: Encapsulation in liposomes containing surface‐bound PEG significantly limits the distribution and elimination of doxorubicin, results in greater accumulation of the drug in KS lesions 72 hours after dosing than does standard dox orubic in, and may improve drug efficacy and therapeutic index in the treatment of AIDS‐KS.
Patent
Microreservoir liposome composition and method
TL;DR: In this paper, a liposome composition for extended release of a therapeutic compound into the bloodstream is presented. But the composition is composed of vesicle-forming lipids and between 1-20 mole percent of a vesicles-forming lipid derivatized with hydrophilic polymer, and the size ranges between 0.1 and 0.4 microns.
Patent
Therapeutic liposome composition and method of preparation
TL;DR: In this paper, a target-cell sensitized liposome composition is formed by incubating the pre-formed liposomal composition with a selected conjugate, such as a lipid, a hydrophilic polymer and a targeting ligand.