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Samuel Zalipsky
Researcher at Alza
Publications - 34
Citations - 3269
Samuel Zalipsky is an academic researcher from Alza. The author has contributed to research in topics: Liposome & Polyethylene glycol. The author has an hindex of 18, co-authored 34 publications receiving 3212 citations. Previous affiliations of Samuel Zalipsky include Rutgers University.
Papers
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Journal ArticleDOI
Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates.
Patent
Lipid-polymer conjugates and liposomes
TL;DR: In this paper, a lipid-polymer conjugate for long-circulating liposomes is presented. But the conjugates do not include a vesicle-forming lipid having convalently attached to its polar head group, such as polyvinylpyrrolidone or polyaspartamide.
Journal ArticleDOI
New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes.
TL;DR: This is the first demonstration of protection from rapid recognition and clearance conveyed by alternative polymers, which is equal to the effect of PEG.
Patent
Solid-tumor treatment method
TL;DR: In this article, a method of administering an anti-tumor compound to a subject is disclosed, which includes a surface coating of polyethylene glycol chains, at a surface concentration thereof sufficient to extend the blood circulation time of the liposomes severalfold over that of liposome in the absence of such coating, and surface-attached antibody molecules effective to bind specifically to tumorassociated antigens present at the tumor site.
Journal ArticleDOI
Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly(ethylene glycol).
TL;DR: While formulation of pH‐sensitive DOPE/cholesterol hemisuccinate liposomes with mPEG‐DTP‐DSPE abolished the pH sensitivity, cleavage of the PEG chains completely restored this property.