F
Francisco Gracia-Navarro
Researcher at University of Córdoba (Spain)
Publications - 112
Citations - 2693
Francisco Gracia-Navarro is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: Somatotropic cell & Somatostatin. The author has an hindex of 26, co-authored 110 publications receiving 2557 citations. Previous affiliations of Francisco Gracia-Navarro include Carlos III Health Institute & Rafael Advanced Defense Systems.
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Journal ArticleDOI
Intracellular Signaling Mechanisms Mediating Ghrelin-Stimulated Growth Hormone Release in Somatotropes
María M. Malagón,Raúl M. Luque,Ernesto Ruiz-Guerrero,Francisca Rodríguez-Pacheco,Socorro García-Navarro,Felipe F. Casanueva,Francisco Gracia-Navarro,Justo P. Castaño +7 more
TL;DR: The results indicate that ghrelin exerts a direct stimulatory action on porcine GH release that is not additive with that of GHRH and requires the contribution of a multiple, complex set of interdependent intracellular signaling pathways.
Journal ArticleDOI
Identification and Characterization of Two Novel Truncated but Functional Isoforms of the Somatostatin Receptor Subtype 5 Differentially Present in Pituitary Tumors
Mario Durán-Prado,Manuel D. Gahete,Antonio J. Martínez-Fuentes,Raúl M. Luque,Ana Quintero,Susan M. Webb,Pedro Benito-López,Alfonso Leal,Stefan Schulz,Francisco Gracia-Navarro,María M. Malagón,Justo P. Castaño +11 more
TL;DR: The results demonstrate the existence of two previously unidentified sst5 spliced variants with distinct distribution in normal tissues and pituitary tumors, unique ligand-selective signaling properties, and subcellular distribution, which could contribute to somatostatin and cortistatin signaling in normal and tumoral cells.
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Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.
Manuel D. Gahete,Mario Durán-Prado,Raúl M. Luque,Antonio J. Martínez-Fuentes,Ana Quintero,Ester Gutiérrez-Pascual,Jose Cordoba-Chacon,María M. Malagón,Francisco Gracia-Navarro,Justo P. Castaño +9 more
TL;DR: Teleosts exhibit a multifactorial regulation of GH secretion, with a number of factors, from the newly discovered fish GH‐releasing hormone to pituitary adenylate cyclase‐activating peptide to somatostatin, which enable a balanced integration of feedback signals related to processes in which GH plays a relevant regulatory role.
Journal ArticleDOI
Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity
Marina R. Pulido,Alberto Diaz-Ruiz,Yolanda Jimenez-Gomez,Socorro García-Navarro,Francisco Gracia-Navarro,Francisco J. Tinahones,Jose Lopez-Miranda,Gema Frühbeck,Rafael Vázquez-Martínez,María M. Malagón +9 more
TL;DR: The data support the view that Rab18 is a common mediator of lipolysis and lipogenesis and suggests that the endoplasmic reticulum (ER) is the link that enables Rab18 action on these two processes and a role for Rab18 in the regulation of adipocyte biology under both normal and pathological conditions is proposed.
Journal ArticleDOI
Expression of the Ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients
Manuel D. Gahete,Alicia Rubio,Jose Cordoba-Chacon,Francisco Gracia-Navarro,Rhonda D. Kineman,Rhonda D. Kineman,Jesús Avila,Raul M Luque,Justo P. Castaño +8 more
TL;DR: In this paper, the authors used real-time RT-PCR to analyze expression of the ghrelin/NTS axis in one of the cortical regions most affected in Alzheimer's disease, the temporal gyrus.