F
Francisco León
Researcher at University of Florida
Publications - 196
Citations - 3963
Francisco León is an academic researcher from University of Florida. The author has contributed to research in topics: Mitragynine & Mitragyna speciosa. The author has an hindex of 30, co-authored 191 publications receiving 3035 citations. Previous affiliations of Francisco León include University of Mississippi & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo‐controlled study
Ciaran P. Kelly,Peter H.R. Green,Joseph A. Murray,Anthony J. DiMarino,Anthony M. Colatrella,Daniel A. Leffler,T. Alexander,Razvan Arsenescu,Francisco León,John Jiang,L. A. Arterburn,B. M. Paterson,Richard N. Fedorak +12 more
TL;DR: Larazotide acetate is a first‐in‐class oral peptide that prevents tight junction opening, and may reduce gluten uptake and associated sequelae.
Journal ArticleDOI
A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge
Daniel A. Leffler,Ciaran P. Kelly,H Z Abdallah,Anthony M. Colatrella,Lucinda A. Harris,Francisco León,L. A. Arterburn,B. M. Paterson,Z H Lan,Joseph A. Murray +9 more
TL;DR: Lazotide acetate appeared to limit gluten-induced worsening of gastrointestinal symptom severity as measured by the Gastrointestinal Symptom Rating Scale at some lower doses but not at the higher dose, suggesting that 2.4 g of gluten per day is sufficient to induce reproducible gluten toxicity.
Journal ArticleDOI
Peyer's Patch Dendritic Cells Process Viral Antigen from Apoptotic Epithelial Cells in the Intestine of Reovirus-infected Mice
Marina Fleeton,Nikhat Contractor,Francisco León,J. Denise Wetzel,Terence S. Dermody,Brian L. Kelsall +5 more
TL;DR: These studies show that CD8α−/CD11blo DCs in the PP SED process T1L antigen from infected apoptotic epithelial cells for presentation to CD4+ T cells, and therefore demonstrate the cross-presentation of virally infected cells by DC's in vivo during a natural viral infection.
Journal ArticleDOI
Human small-intestinal epithelium contains functional natural killer lymphocytes.
TL;DR: This is the first demonstration of functional natural killer cells within the human gut epithelium and these cells might play an important role in innate mucosal immunity (host defense and tumor surveillance) and tolerance.
Journal ArticleDOI
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine
TL;DR: The present findings indicate that MG does not have abuse potential and reduces morphine intake, desired characteristics of candidate pharmacotherapies for opiate addiction and withdrawal, whereas 7‐HMG should be considered a kratom constituent with high abuse potential that may also increase the intake of other opiates.