F
Francisco Miralles
Researcher at Paris Descartes University
Publications - 36
Citations - 1863
Francisco Miralles is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Pancreas & Placenta. The author has an hindex of 18, co-authored 33 publications receiving 1587 citations. Previous affiliations of Francisco Miralles include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Oxidative Stress in Preeclampsia and Placental Diseases.
TL;DR: This review presents the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models, and assess the putative effects of these free radicals on the placenta and maternal endothelium.
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Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.
TL;DR: Follistatin, which is expressed by E12.5 pancreatic mesenchyme, could represent one of the mesenchymal factors required for the development of the exocrine tissue while exerting a repressive role on the differentiation of the endocrine cells.
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Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
TL;DR: It is shown that FGFs signaling through FGFR-2 IIIb play an important role in the development of the exocrine pancreas and that in mesenchyme-free cultures of embryonic pancreatic epithelium FGF-1, F GF-7, and FGF
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TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2
TL;DR: During rat pancreatic development, matrix metalloproteinase 2 (MMP-2) is activated in vivo between E17 and E19 when islet morphogenesis occurs, and it is demonstrated that in vitro, TGF-β is a key activator of pancreatic M MP-2, and that MMP- 2 activity is necessary for islet Morphogenesis.
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The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
TL;DR: The potential use of epigenetic marks circulating in the maternal blood flow as putative biomarkers able to prognosticate the onset of PE are explored, as well as classifying it according to its severity.