A review of natural products with antileishmanial activity

http://maltawildplants.com/ASTR/Docs/CLDBC/Leish.pdf

Plant natural products with leishmanicidal activity.

The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

https://www.mdpi.com/1420-3049/24/10/2001/pdf

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Fine Chemicals Angeles Farrań,† Chao Cai,‡ Manuel Sandoval, Yongmei Xu, Jian Liu, María J. Hernaíz,* and Robert J. Linhardt* †Departamento de Química Orgańica y Bio-Orgańica, Facultad de Ciencias, Universidad Nacional de Educacioń a Distancia, Paseo Senda del Rey 4, 28040 Madrid, Spain ‡Key Laboratory of Marine Drugs of Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China Escuela de Química, Universidad Nacional of Costa Rica, Post Office Box 86, 3000 Heredia, Costa Rica Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States Center for Biotechnology & Interdisciplinary Studies and Department of Chemistry & Chemical Biology, Rensselaer Polytechnic Institute, Biotechnology Center 4005, Troy, New York 12180, United States Departamento de Química Orgańica y Farmaceútica, Facultad de Farmacia, Universidad Complutense de Madrid, Pz/Ramoń y Cajal s/n, 28040 Madrid, Spain

Green solvents in carbohydrate chemistry: from raw materials to fine chemicals.

Antioxidant properties of Mediterranean spices compared with common food additives.

Solution-and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides

Microbial Transformation of Triterpenoids

Biotransformation of oleanolic and maslinic acids by Rhizomucor miehei.

A significant number of terpenoid compounds are glycosides with the sugars linked to the active groups. Sometimes, the glycosidic residue is crucial for their activity, but in other cases glycosylation only improves pharmacokinetic parameters. Enzymatic glycosylation of terpenoids is a useful tool due to the high selectivity and the mildness of the reaction conditions, in comparison with chemical methods. Several types of biocatalysts have been used in the enzymatic glycosylation of terpenoids. These include the use of glycosyltransferases, trans-glycosidases, and whole-cell biotransformation systems capable of regenerating the cofactor, such as fungi, bacteria, plant-cell cultures, etc. Many biosynthesized terpenoid glycosides display medicinal and pharmacological properties and can be used as pro-drug substances. These terpenoid glycosides have also been employed as food additives (e.g. low-caloric sweetener compounds) and cosmetics, and even have applications as controlled-release fragrances.

Francisco Rivas

Papers

Solution-and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides

Microbial Transformation of Triterpenoids

Biotransformation of oleanolic and maslinic acids by Rhizomucor miehei.

Enzymatic glycosylation of terpenoids

Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells