Franck Amblard

TL;DR: The classic Huisgen 1,3-dipolar cycloaddition reaction between acetylenes and azides was brought back into focus by Sharpless and others when they developed the concept of click chemistry as mentioned in this paper.

TL;DR: For many decades, the design of new nucleoside analogs as potential therapeutic agents focused on both sugar and nucleobase modifications, but now nucleosides triphosphates cannot be considered as viable drug candidates as they usually have poor chemical stability along with high polarity that hinders them from transporting across cell membranes.

TL;DR: This review focuses on the chemical synthesis and biology of anticancer nucleoside, nucleotide, and base analogs that are FDA-approved and in clinical development since 2000 and explores analog syntheses as well as improved and scale-up syntheses.

TL;DR: Nucleoside analogs that target the HCV NS5B polymerase that have reached human clinical trials is the focus of this review as they have demonstrated significant advantages in the clinic with broader activity against the various HCV GT and a higher barrier to the development of resistant viruses when compared to all other classes of HCV inhibitors.

TL;DR: In vitro and in vivo activity of HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer.