Judy S. Mathew

TL;DR: These studies demonstrate that modification of the sugar ring of cytosine nucleoside analogs with a 4′-thia instead of an oxygen results in compounds with the ability to potently inhibit wild-type HIV-1 but with reduced potency against lamivudine-resistant virus.

TL;DR: From the leaves of Millettia erythrocalyx, a new flavone named 3′,5′-dimethoxy-[2′′,3′′ : 7,8]-furanoflavone and three known compounds were isolated and oxyresveratrol was evaluated for potential anti-HIV activity against a wild-type human immunodeficiency virus type 1 isolate.

TL;DR: Nucleoside analogs that target the HCV NS5B polymerase that have reached human clinical trials is the focus of this review as they have demonstrated significant advantages in the clinic with broader activity against the various HCV GT and a higher barrier to the development of resistant viruses when compared to all other classes of HCV inhibitors.

TL;DR: Molecular modeling studies suggest that the pattern of antiviral activity, similar to that of beta-l-2'-F-d4N, stemmed from their conformational and structural similarities.

TL;DR: As antiviral nucleosides containing a 2',3'-unsaturated sugar moiety with 2'-fluoro substitution are endowed with increased stabilization of the glycosyl bond, it was of interest to investigate the influence of the fluorine atom at the 3'-position to suggest that, in addition to the sugar conformation, the base moiety may also play a role in their interaction with the M184V RT.