H
H. Phillip Koeffler
Researcher at Cedars-Sinai Medical Center
Publications - 492
Citations - 33849
H. Phillip Koeffler is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Gene & Cell growth. The author has an hindex of 92, co-authored 479 publications receiving 29428 citations. Previous affiliations of H. Phillip Koeffler include Kagawa University & Humboldt University of Berlin.
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Journal ArticleDOI
Maftools: efficient and comprehensive analysis of somatic variants in cancer.
Anand Mayakonda,Anand Mayakonda,De-Chen Lin,Yassen Assenov,Yassen Assenov,Christoph Plass,Christoph Plass,H. Phillip Koeffler,H. Phillip Koeffler +8 more
TL;DR: An R Bioconductor package, Maftools, is described, which offers a multitude of analysis and visualization modules that are commonly used in cancer genomic studies, including driver gene identification, pathway, signature, enrichment, and association analyses, and is independent of larger alignment files.
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Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Masashi Shiosaka,Ryoichiro Kawahata,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,H. Phillip Koeffler,Lee Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +32 more
TL;DR: The results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia.
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Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3
TL;DR: It is shown that 1,25‐dihydroxyvitamin D3 and three of its analogs induced expression of the human cathelicidin antimicrobial peptide (CAMP) gene, which is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1, 25‐dietary D3.
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The Circadian Gene Per1 Plays an Important Role in Cell Growth and DNA Damage Control in Human Cancer Cells
TL;DR: It is reported here that Per1 provides an important link between the circadian system and the cell cycle system and support the hypothesis that disruption of core clock genes may lead to cancer development.
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Genomic and molecular characterization of esophageal squamous cell carcinoma
De-Chen Lin,De-Chen Lin,Jia-Jie Hao,Yasunobu Nagata,Liang Xu,Li Shang,Xuan Meng,Yusuke Sato,Yusuke Okuno,Ana Maria Varela,Ling-Wen Ding,Manoj Garg,Li-Zhen Liu,Henry Yang,Dong Yin,Zhi-Zhou Shi,Yan-Yi Jiang,Wen-Yue Gu,Ting Gong,Yu Zhang,Xin Xu,Ori Kalid,Sharon Shacham,Seishi Ogawa,Ming-Rong Wang,H. Phillip Koeffler,H. Phillip Koeffler +26 more
TL;DR: The whole-exome or targeted deep sequencing of 139 paired ESCC cases and analysis of somatic copy number variations (SCNV) of over 180 ESCCs provide an important molecular foundation for understanding esophageal tumors and developing therapeutic targets.