F
Franco Fiaccadori
Researcher at University of Parma
Publications - 70
Citations - 6718
Franco Fiaccadori is an academic researcher from University of Parma. The author has contributed to research in topics: Antigen & Hepatitis B virus. The author has an hindex of 35, co-authored 70 publications receiving 6613 citations. Previous affiliations of Franco Fiaccadori include Sapienza University of Rome & University of L'Aquila.
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Journal ArticleDOI
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
Gabriele Missale,Roberto Bertoni,Vincenzo Lamonaca,A Valli,Marco Massari,Cristina Mori,Maria Grazia Rumi,Michael Houghton,Franco Fiaccadori,Carlo Ferrari +9 more
TL;DR: Responses to all hepatitis C virus antigens were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not, suggesting that the vigor of the T cell response during the early stages of infection may be a critical determinant of disease resolution and control.
Journal ArticleDOI
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
Antonio Bertoletti,Alessandro Sette,Francis V. Chisari,Amalia Penna,Massimo Levrero,Marco De Carli,Franco Fiaccadori,Carlo Ferrari +7 more
TL;DR: It is reported here that hepatitis B virus isolates derived from two chronically infected patients display variant epitopes that act as natural TCR antagonists with the capacity to inhibit the CTL response to the wild-type epitope.
Journal Article
Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
Carlo Ferrari,Amalia Penna,Antonio Bertoletti,A Valli,A D Antoni,Tiziana Giuberti,A. Cavalli,Marie-Anne Petit,Franco Fiaccadori +8 more
TL;DR: The results indicate HBV-infected subjects who develop a self-limited acute hepatitis show a vigorous PBMC response to hepatitis B core Ag and HBeAg, as expression of T cell activation, which may reflect immune events of pathogenetic relevance with respect to evolution of disease and viral clearance.
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Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.
Carolina Boni,Antonio Bertoletti,Amalia Penna,A. Cavalli,Massimo Pilli,Simona Urbani,Paola Scognamiglio,Richard Boehme,Ruggero Panebianco,Franco Fiaccadori,Carlo Ferrari +10 more
TL;DR: An efficient antiviral T cell response can be restored by lamivudine treatment in patients with chronic hepatitis B concurrently with reduction of viremia, indicating the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients.
Journal ArticleDOI
Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.
Amalia Penna,Francis V. Chisari,Antonio Bertoletti,Gabriele Missale,P Fowler,Tiziana Giuberti,Franco Fiaccadori,Carlo Ferrari +7 more
TL;DR: This study provides the first direct evidence of HLA class I-restricted T cell cytotoxicity against HBV in humans and suggests a pathogenetic role for this CTL activity in the clearance of HBV infection.