F
François Paquet-Durand
Researcher at University of Tübingen
Publications - 98
Citations - 3819
François Paquet-Durand is an academic researcher from University of Tübingen. The author has contributed to research in topics: Retinal degeneration & Retinitis pigmentosa. The author has an hindex of 32, co-authored 95 publications receiving 3151 citations. Previous affiliations of François Paquet-Durand include Lund University & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration
Javier Sancho-Pelluz,Blanca Arango-Gonzalez,Stefan Kustermann,Francisco J. Romero,Theo van Veen,Eberhart Zrenner,Per Ekström,François Paquet-Durand +7 more
TL;DR: A putative non-apoptotic molecular pathway for photoreceptor cell death in the rd1 retina is proposed based on recent experimental evidence and may provide new ideas for future treatment of RP.
Journal ArticleDOI
Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration
Gesine Huber,Susanne C. Beck,Christian Grimm,Ayse Sahaboglu-Tekgöz,François Paquet-Durand,Andreas Wenzel,Peter Humphries,T. Michael Redmond,Mathias W. Seeliger,M. Dominik Fischer +9 more
TL;DR: Cross-sectional visualization of retinal structures in wild-type mice and mouse models for retinal degeneration in vivo is demonstrated using a commercially available SD-OCT device to facilitate characterization of disease dynamics and evaluation of putative therapeutic effects after experimental interventions.
Journal ArticleDOI
Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.
Blanca Arango-Gonzalez,Dragana Trifunović,Ayse Sahaboglu,Katharina Kranz,Stylianos Michalakis,Pietro Farinelli,Susanne Koch,Fred Koch,Sandra Cottet,Ulrike Janssen-Bienhold,Karin Dedek,Martin Biel,Eberhart Zrenner,Thomas Euler,Per Ekström,Marius Ueffing,François Paquet-Durand +16 more
TL;DR: It is shown that apoptosis plays only a minor role in the inherited forms of retinal neurodegeneration studied, where instead, a non-apoptotic degenerative mechanism common to all mutants is of major importance.
Journal ArticleDOI
Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
Stylianos Michalakis,Regine Mühlfriedel,Naoyuki Tanimoto,Vidhyasankar Krishnamoorthy,Susanne Koch,M. Dominik Fischer,Elvir Becirovic,Lin Bai,Gesine Huber,Susanne C. Beck,E. Fahl,Hildegard Büning,François Paquet-Durand,Xiangang Zong,Tim Gollisch,Martin Biel,Mathias W. Seeliger +16 more
TL;DR: In this paper, the authors introduced viral gene replacement therapy as a potential treatment for this disease in the CNGA3−/− mouse model and showed that such therapy can restore cone-specific visual processing in the central nervous system even if cone photoreceptors had been nonfunctional from birth.
Journal Article
Restoration of Cone Vision in the CNGA3(-/-) Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
Stylianos Michalakis,Regine Mühlfriedel,Naoyuki Tanimoto,Vidhyasankar Krishnamoorthy,Susanne Koch,M. D. Fischer,Elvir Becirovic,L. Bai,Gesine Huber,Susanne C. Beck,E. Fahl,Hildegard Büning,François Paquet-Durand,Xiangang Zong,Tim Gollisch,Martin Biel,M. W. Seeliger +16 more
TL;DR: It is shown that viral gene replacement therapy can restore cone-specific visual processing in the central nervous system even if cone photoreceptors had been nonfunctional from birth and that this newly acquired sensory information was translated into cone-mediated, vision-guided behavior.