F
François Taddei
Researcher at Paris Descartes University
Publications - 96
Citations - 10684
François Taddei is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Population & Gene. The author has an hindex of 46, co-authored 95 publications receiving 9916 citations. Previous affiliations of François Taddei include French Institute of Health and Medical Research & École Normale Supérieure.
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Journal ArticleDOI
Robust growth of Escherichia coli.
Ping Wang,Lydia Robert,Lydia Robert,James F. Pelletier,Wei Lien Stephen Dang,François Taddei,Andrew Wright,Suckjoon Jun +7 more
TL;DR: The long-term growth and division patterns of Escherichia coli cells are studied by employing a microfluidic device designed to follow steady-state growth anddivision of a large number of cells at a defined reproductive age to conclude that E. coli has a robust mechanism of growth that is decoupled from cell death.
Journal ArticleDOI
Stress-Induced Mutagenesis in Bacteria
Ivana Bjedov,Ivana Bjedov,Olivier Tenaillon,Olivier Tenaillon,Bénédicte Gérard,Bénédicte Gérard,Valeria Souza,Valeria Souza,Erick Denamur,Erick Denamur,Miroslav Radman,Miroslav Radman,François Taddei,François Taddei,Ivan Matic,Ivan Matic +15 more
TL;DR: It is suggested that irrespective of the causes of their emergence, stress-induced mutations participate in adaptive evolution and could be a by-product of genetic strategies for improving survival under stress.
Journal ArticleDOI
Role of mutator alleles in adaptive evolution
François Taddei,François Taddei,Miroslav Radman,John Maynard-Smith,Bruno Toupance,Pierre-Henri Gouyon,Bernard Godelle,Bernard Godelle +7 more
TL;DR: Whether high mutation rates might play an important role in adaptive evolution is considered, as models of large, asexual, clonal populations adapting to a new environment show that strong mutator genes can accelerate adaptation, even if the mutator gene remains at a very low frequency.
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Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division
Eric J. Stewart,Eric J. Stewart,Richard Madden,Gregory Paul,Gregory Paul,François Taddei,François Taddei +6 more
TL;DR: It is concluded that the two supposedly identical cells produced during cell division are functionally asymmetric; the old pole cell should be considered an aging parent repeatedly producing rejuvenated offspring and therefore immortality may be either too costly or mechanistically impossible in natural organisms.
Journal ArticleDOI
Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation
TL;DR: This work followed the appearance and inheritance of spontaneous protein aggregation within lineages of Escherichia coli grown under nonstressed conditions using time-lapse microscopy and a fluorescently tagged chaperone involved in aggregate processing to faithfully identify in vivo the localization of aggregated proteins.