F
Françoise J. Smith
Researcher at Hoffmann-La Roche
Publications - 17
Citations - 8224
Françoise J. Smith is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Leptin & Adipose tissue. The author has an hindex of 15, co-authored 17 publications receiving 8035 citations. Previous affiliations of Françoise J. Smith include University of Washington.
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Journal ArticleDOI
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.
TL;DR: The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance in ob/ob and diet-induced obese mice.
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Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Dennis Huszar,Catherine A. Lynch,Victoria Fairchild-Huntress,Judy H. Dunmore,Qing Fang,Lucy R Berkemeier,Wei Gu,Robert A. Kesterson,Bruce A. Boston,Roger D. Cone,Françoise J. Smith,L. Arthur Campfield,Paul Burn,Frank W. Lee +13 more
TL;DR: The data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R.
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The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks.
TL;DR: It is demonstrated that central administration of OB protein lead to reductions in food intake, body weight and alterations in metabolism consistent with activation of the autonomic nervous system and this may be one of the mechanisms of reduced sensitivity of the OB protein pathway in obese individuals.
Journal ArticleDOI
Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats.
Randy J. Seeley,G. Van Dijk,L A Campfield,Françoise J. Smith,Paul Burn,J. A. Nelligan,S. M. Bell,Denis G. Baskin,Stephen C. Woods,Michael W. Schwartz +9 more
TL;DR: Results are consistent with the hypothesis that leptin has direct actions in the CNS as an afferent signal related to the state of energy stores in adipose tissue and insensitivity to these central effects of leptin may be an important determinant of obesity.
Journal ArticleDOI
Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats
Todd E. Thiele,G. Van Dijk,L. A. Campfield,Françoise J. Smith,Paul Burn,Stephen C. Woods,Ilene L. Bernstein,Randy J. Seeley +7 more
TL;DR: The results indicate that central GLP-1 produces aversive side effects, and it is argued that these nonspecific effects may explain the anorectic actions of GLp-1.