Victoria Fairchild-Huntress

TL;DR: The data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R.

TL;DR: The role of Smad6 in the homeostasis of the adult cardiovascular system is indicated by the development of aortic ossification and elevated blood pressure in viable mutants, and defects highlight the importance of Smads in the tissue-specific modulation of Tgf-β superfamily signalling pathways in vivo.

TL;DR: Metabolic studies using HDL bearing nondegradable radiolabels in both the protein and lipid components demonstrated that reducing hepatic SR-BI expression by half was associated with a decrease in selective uptake of CE by the liver, and a corresponding reduction of 53% in selective removal of HDL-CE from plasma.

TL;DR: The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.

TL;DR: Spontaneous downregulation of the ACE2 transgene in surviving older animals correlated with restoration of nearly normal conduction, rhythm, and connexin expression, indicating that ACE2-mediated gap junction remodeling may account for the observed electrophysiologic disturbances.