F
Frank D. Yocca
Researcher at Bristol-Myers Squibb
Publications - 58
Citations - 2604
Frank D. Yocca is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 25, co-authored 54 publications receiving 2512 citations. Previous affiliations of Frank D. Yocca include City University of New York.
Papers
More filters
Journal ArticleDOI
Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors
Kevin D. Burris,Thaddeus F. Molski,Cen Xu,Elaine Ryan,Katsura Tottori,Tetsuro Kikuchi,Frank D. Yocca,Perry B. Molinoff +7 more
TL;DR: These results, together with previous studies demonstrating partial agonist activity at serotonin 5-hydroxytryptamine (5-HT)1A receptors and antagonist activity at 5-HT2A receptors, support the identification of aripiprazole as a dopamine-serotonin system stabilizer.
Journal ArticleDOI
Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies
Arlene Stark,Shaun Jordan,Kelly A. Allers,Robert L. Bertekap,Ruoyan Chen,Tanaz Mistry Kannan,Thaddeus F. Molski,Frank D. Yocca,Trevor Sharp,Tetsuro Kikuchi,Kevin D. Burris +10 more
TL;DR: Results support a partial agonist activity for aripiprazole at 5-HT1A receptors in vitro and in vivo, and suggest important interactions with other 4-HT-receptor subtypes and this receptor activity profile may contribute to the antipsychotic activity of aripine in humans.
Journal ArticleDOI
BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes.
Journal ArticleDOI
Phase Shifting of Circadian Rhythms and Depression of Neuronal Activity in the Rat Suprachiasmatic Nucleus by Neuropeptide Y: Mediation by Different Receptor Subtypes
Valentin K. Gribkoff,Rick L. Pieschl,Todd A. Wisialowski,Anthony N. van den Pol,Frank D. Yocca +4 more
TL;DR: These are the first data to indicate that at least two functional populations of NPY receptors exist in the SCN, distinguishable on the basis of pharmacology, each mediating a different physiological response to NPY application.
Journal Article
Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.
Frank D. Yocca,L Iben,E Meller +2 more
TL;DR: This was directly determined by examining the relationship between receptor occupancy and response at postsynaptic 5-HT1A receptors, in rat hippocampus, mediating the inhibition of forskolin-stimulated adenylyl cyclase activity, using the method of partial irreversible receptor inactivation.