V
Valentin K. Gribkoff
Researcher at Yale University
Publications - 134
Citations - 6181
Valentin K. Gribkoff is an academic researcher from Yale University. The author has contributed to research in topics: Excitatory postsynaptic potential & BK channel. The author has an hindex of 42, co-authored 129 publications receiving 5814 citations. Previous affiliations of Valentin K. Gribkoff include Marine Biological Laboratory & Tulane University.
Papers
More filters
Journal ArticleDOI
Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
Chen Liu,David R. Weaver,Xiaowei Jin,Lauren P. Shearman,Rick L. Pieschl,Valentin K. Gribkoff,Steven M. Reppert +6 more
TL;DR: The results provide a molecular basis for two distinct, mechanistically separable effects of melatonin on SCN physiology.
Journal ArticleDOI
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.
Valentin K. Gribkoff,John E. Starrett,Steven I. Dworetzky,Piyasena Hewawasam,Christopher G. Boissard,Deborah A. Cook,Stephen W. Frantz,Karen Heman,Jeffrey R. Hibbard,Kevin Huston,Graham Johnson,Bala Krishnan,Gene G. Kinney,Lynn A. Lombardo,Nicholas A. Meanwell,Perry B. Molinoff,Robert A. Myers,Sandra L. Moon,Astrid A. Ortiz,Lorraine Pajor,Rick L. Pieschl,Debra J. Post-Munson,Laura J. Signor,N.R. Srinivas,Matthew T. Taber,George Thalody,Joanne T. Trojnacki,Harvey Wiener,Krishnaswamy Yeleswaram,Sarita W Yeola +29 more
TL;DR: The novel fluoro-oxindoles BMS-204352 and racemic compound 1 are potent, effective and uniquely Ca++-sensitive openers of maxi-K channels, thereby augmenting an endogenous mechanism for regulating Ca++ entry and membrane potential.
Journal ArticleDOI
Targeted disruption of the mouse Mel(1b) melatonin receptor.
Xiaowei Jin,Charlotte von Gall,Charlotte von Gall,Rick L. Pieschl,Valentin K. Gribkoff,Jörg H. Stehle,Steven M. Reppert,Steven M. Reppert,David R. Weaver,David R. Weaver +9 more
TL;DR: The role of the mammalian Mel1a and Mel1b receptor subtypes in mediating a response to the hormone occurring at higher ligand concentrations in mice lacking the Mel 1a melatonin receptor was investigated in this article.
Journal ArticleDOI
Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.
Steven I. Dworetzky,Christopher G. Boissard,J T Lum-Ragan,M. C. Mckay,Debra J. Post-Munson,Joanne T. Trojnacki,Chang Cp,Valentin K. Gribkoff +7 more
TL;DR: A human homolog of the large-conductance calcium-activated potassium (BK) channel β-subunit (hSlo β) was cloned and its effects on a human BK channel ( hSlo ) phenotype are reported in this paper.
Journal ArticleDOI
The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.
TL;DR: Some of the reasons for failure are reviewed, delineating both scientific and technical realities, some unique to the CNS, that have contributed to this, to suggest some changes that may improve outcomes in future CNS‐targeted drug discovery and development efforts.