S
Smith David W
Researcher at Merck & Co.
Publications - 49
Citations - 5063
Smith David W is an academic researcher from Merck & Co.. The author has contributed to research in topics: Amyloid precursor protein & Long-term potentiation. The author has an hindex of 27, co-authored 49 publications receiving 4909 citations. Previous affiliations of Smith David W include Bristol-Myers Squibb.
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Journal ArticleDOI
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation
François G. Gervais,Daigen Xu,George S. Robertson,John P. Vaillancourt,Yanxia Zhu,JingQi Huang,Andréa C. LeBlanc,Smith David W,Michael Rigby,Mark S. Shearman,Earl E. Clarke,Hui Zheng,Leonardus H. T. Van Der Ploeg,Salvatore C. Ruffolo,Nancy A. Thornberry,Steve Xanthoudakis,Robert Zamboni,Sophie Roy,Donald W. Nicholson +18 more
TL;DR: Caspases appear to play a dual role in proteolytic processing of APP and the resulting propensity for Aβ peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease.
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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
Hui Zheng,Minghao Jiang,Myrna E. Trumbauer,Dalip J. S. Sirinathsinghji,R. Hopkins,Smith David W,Robert P. Heavens,Gerard R. Dawson,Susan Boyce,Michael W. Conner,Karla Stevens,Hilda H. Slunt,Sangram S. Sisodia,Howard Y. Chen,Lex H.T. Van der Ploeg +14 more
TL;DR: To understand the in vivo function of APP and its processing, an APP-null mutation is generated in mice and it is shown that the APP-deficient mice exhibited a decreased locomotor activity and forelimb grip strength, indicating a compromised neuronal or muscular function.
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Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
Gerard R. Dawson,Guy R. Seabrook,Hui Zheng,Smith David W,S Graham,G O'Dowd,B.J. Bowery,Susan Boyce,Myrna E. Trumbauer,Howard Y. Chen,L. H. T. Van Der Ploeg,Dalip J. S. Sirinathsinghji +11 more
TL;DR: It is suggested that normal beta-amyloid precursor protein may serve an essential role in the maintenance of synaptic function during ageing and may contribute to the progression of the memory decline and the neurodegenerative changes seen in Alzheimer's disease.
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Molecular and functional diversity of the expanding GABA-A receptor gene family.
Paul J. Whiting,Timothy P. Bonnert,Ruth M. McKernan,Sophie J. Farrar,Beatrice Le Bourdelles,Robert P. Heavens,Smith David W,Louise Hewson,Michael Rigby,Dalip J. S. Sirinathsinghji,Sally A. Thompson,Keith A. Wafford +11 more
TL;DR: A picture is beginning to emerge of the properties conferred to receptor subtypes by the different subunits; these include different functional properties, differential modulation by protein kinases, and the targeting to different membrane compartments.
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Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
TL;DR: It is demonstrated that moderately elevated corticosterone for a prolonged period is sufficient to induce cellular changes in the hippocampus that are prevented by chronic administration of antidepressants.