Showing papers in "European Journal of Pharmacology in 1987"

TL;DR: The release of nitric oxide from organic nitrates is examined by means of a difference-spectrophotometric method and it is found that the results correlated well with the extent of enzyme activation, suggesting both an enzymatic and a non-enzymatic mode of inhibition of enzyme activity does exist.

TL;DR: Describing binding sites labeled by [3H]p-aminoclonidine in bovine brain membranes prepared from the ventrolateral medulla found that these sites may mediate, in part, the hypotensive action of clonidine and other imidazole compounds in the ventral medulla.

TL;DR: The results suggest that acute nicotine shares with other drugs of abuse the characteristic of being more effective in stimulating A10 than A9 neurons, and that dopamine receptors are not directly involved in the nicotinic action.

TL;DR: To examine this hypothesis in neonatal brain, MK-80I , a novel noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested using an in vivo experimental model of hypoxic-ischemic forebrain injury.

TL;DR: The results indicate that efficacies in the adenylate cyclase assay are dissociated from those on behaviour and indicate that in normal rats D-1 receptors are functionally relevant since D- 1 agonists facilitate the expression of oral stereotyped behaviour after combination with a D-2 agonist.

TL;DR: The results suggest that 5-HT1A agonists may have rapid antidepressant properties and that vehicle-treated restrained rats showed reduced locomotor activity and increased defaecation in an open field test the day after the end of restraint.

TL;DR: A microdialysis/smallbore chromatographic system was used to monitor changes in extracellular dopamine concentration in the striatum of the rat following administration of drugs that block catecholamine uptake and the order of potency in vivo was nomifensine greater than cocaine greater than benztropine.

TL;DR: It is concluded that stimulation of either 5-HT1A or5-HT2 receptors results in an activation of the hypothalamic-pituitary-adrenal axis in the rat.

TL;DR: The possibility is proposed that a distinct membrane-bound 'steroid site' coupled to the GBR-Cl- ionophore complex exists and is reported for anticonvulsant and anesthetic actions.

TL;DR: The results indicate that alpha 2-adrenoceptors and opiate receptors can interact in the modulation of nociceptive transmission in rat spinal cord.

TL;DR: The role of nitric oxide as terminal activator of guanylate cyclase stimulation by nitrovasodilators is supported, supported by the results of the present study.

TL;DR: Persistence of the anorexic effect of RU 24969 after p-chlorophenylalanine (pCPA) pretreatment suggests that5-HT1B agonists induce anorexia at a postsynaptic 5-HT receptor.

TL;DR: The results indicate that a single pretreatment with 5-HT1A agonists rapidly desensitises 5- HT1A presynaptic receptor-mediated responses, which may mediate the antidepressant-like action of the drugs in an animal model of depression.

TL;DR: There is a sympathetic component, possibly mediated by a DA-1 type receptor in carrageenin-induced hyperalgesia, that may predominate in certain types of pain not sensitive to NSAID and could be developed as a novel class of analgesics.

TL;DR: Pairing of haloperidol to both environments abolished the morphine- and amphetamine-induced place preference and induced strong place preference when paired to the non-preferred environments.

TL;DR: The results show that 8-OH-DPAT, by acting on serotonin neurons in the brain, produces disinhibitory effects in a rat model predictive of antidepressant activity and suggest that serotonin1A agonists such as 8- OH- DPAT could constitute a novel class of rapid-acting antidepressant agents.

TL;DR: The results suggest that mast-cell histamine and an intact sensory nerve supply are essential for the flare response to both SP and NKA, and that CGRP does not potentiate the SP-evoked flare and weal and SP did not seem to enhance the response to C GRP.

TL;DR: The data obtained indicate that CGS 12066B is a reasonably active 5HT1B site agonist, which due to its selectivity as compared to compounds such as TFMPP, will be a useful tool for evaluating the physiological role of such receptors in the mammalian CNS.

TL;DR: MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific for N-methyl-asparate toxicity, is non-competitive and does not entail inhibition of excitatory amino acid receptor binding.

TL;DR: The data suggest that phencyclidine results in a differential regulation of presynaptic release of dopamine in mesolimbic/cortical as opposed to nigrostriatal dopaminergic regions.

TL;DR: The present results suggest that neurokinin B contracts the rat portal vein by activating specific receptors, presumably located on the smooth muscle membrane, different from those of biologically active amines and peptides which are active stimulants of the vein.

TL;DR: The findings suggest that the mucosal protective effect and antisecretory effect of OPC-12759 presumably result from enhancement of the generation of endogenous PGs.

TL;DR: The data provide strong evidence for the role of a pertussis toxin substrate(s) (presumably a G protein(s] in mediating the inhibition induced by the autoreceptor and GABAB receptor on 5-HT neurons in rat dorsal raphe nucleus.

TL;DR: It is concluded that GLU stimulates IPs formation mainly via a QA-like receptor subtype (AA2) and this stimulation is transient and could play a key role during synaptogenesis.

TL;DR: The comparative pharmacology of endothelium-derived relaxing factor (EDRF) and nitric oxide (NO) was studied on isolated strips of rabbit aorta, indicating that EDRF and NO have identical biological activity, stability and susceptibility to inactivation by superoxide anions and haemoglobin.

TL;DR: Findings suggest that D-1 receptor stimulation may play a necessary 'enabling' role for D-2 receptor-mediated functional responses in rat nucleus accumbens neurons.

TL;DR: The dephosphorylation of adenine nucleotides and their analogues by ectonucleotidases on the guinea-pig urinary bladder was studied using HPLC, suggesting that while resistance to degradation does not in itself confer high potency, susceptibility to degrade does limit the potency of ATP and its degradable analogues.