The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

https://science.sciencemag.org/content/sci/258/5081/424.full.pdf

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

https://www.cell.com/cell/pdf/0092-8674(84)90440-9.pdf

Construction and applications of a highly transmissible murine retrovirus shuttle vector.

https://www.cell.com/cell/pdf/0092-8674(82)90356-7.pdf

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. Two subtypes of human T lymphotropic virus (HTLV) are associated with different disease phenotypes. In this article it is shown that marked differences exist in the ability of LTR sequences of these subtypes to function as transcriptional elements in differentiated cell types. It is also shown that trans-acting regulatory factors present in HTLV-infected cells stimulate gene expression directed by these LTR sequences in a type-specific manner. These results have implications for understanding the diverse biological effects of HTLV infection.

https://science.sciencemag.org/content/sci/225/4660/381.full.pdf

Frank Lee

Papers

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

REGULATION OF EARLY ADENOVIRUS mRNA SYNTHESIS