F
Frank Schwede
Researcher at University of Bremen
Publications - 102
Citations - 6095
Frank Schwede is an academic researcher from University of Bremen. The author has contributed to research in topics: Protein kinase A & Second messenger system. The author has an hindex of 35, co-authored 94 publications receiving 5418 citations.
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Journal ArticleDOI
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Jorrit M. Enserink,Anne Elisabeth Christensen,Johan de Rooij,Miranda van Triest,Frank Schwede,Hans G. Genieser,Stein Ove Døskeland,Jonathan L. Blank,Johannes L. Bos +8 more
TL;DR: A novel cAMP analogue is developed, 8CPT-2Me-cAMP, which activates Epac, but not PKA, both in vitro and in vivo, and tests the widespread model that Rap1 mediates cAMP-induced regulation of the extracellular signal-regulated kinase (ERK).
Journal ArticleDOI
cAMP Analog Mapping of Epac1 and cAMP Kinase DISCRIMINATING ANALOGS DEMONSTRATE THAT Epac AND cAMP KINASE ACT SYNERGISTICALLY TO PROMOTE PC-12 CELL NEURITE EXTENSION
Anne Elisabeth Christensen,Frode Selheim,Johan de Rooij,Sarah Dremier,Frank Schwede,Khanh K. Dao,Aurora Martinez,Carine Maenhaut,Johannes L. Bos,Hans G. Genieser,Stein Ove Døskeland +10 more
TL;DR: In this paper, the relative role of cAMP-dependent protein kinase (cAPK) and guanine exchange factor directly activated by cAMP (Epac) was investigated.
Journal ArticleDOI
Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.
Ole Niewoehner,Carmela Garcia-Doval,Jakob T. Rostøl,Christian Berk,Frank Schwede,Laurent Bigler,Jonathan Hall,Luciano A. Marraffini,Martin Jinek +8 more
TL;DR: It is shown that Csm6 proteins are activated through a second messenger generated by the type III interference complex, pointing to an unprecedented mechanism for regulation of CRISPR interference that bears striking conceptual similarity to oligoadenylate signalling in mammalian innate immunity.
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Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells
Guoxin Kang,Jamie W. Joseph,Oleg G. Chepurny,Marie E. Monaco,Michael B. Wheeler,Johannes L. Bos,Frank Schwede,Hans-G. Genieser,George G. Holz +8 more
TL;DR: It is proposed that the interaction of cAMP and Epac to trigger CICR explains, at least in part, the blood glucose-lowering properties of an insulinotropic hormone (glucagon-like peptide-1) now under investigation for use in the treatment of type-2 diabetes mellitus.
Journal ArticleDOI
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor
Savithri Rangarajan,Jorrit M. Enserink,H. Bea Kuiperij,Johan de Rooij,Leo S. Price,Frank Schwede,Johannes L. Bos +6 more
TL;DR: It is demonstrated that external stimuli of cAMP signaling, i.e., isoproterenol, which activates the Gαs-coupled β2-adrenergic receptor can induce integrin-mediated cell adhesion through the Epac-Rap1 pathway.