Frans van Harskamp

TL;DR: It is suggested that dementia and its two major subtypes Alzheimer's disease and vascular dementia are associated with atherosclerosis and that there is an interaction between apolipoprotein E and Atherosclerosis in the aetiology of Alzheimer’s disease.

TL;DR: A novel base mutation in the same exon of the APP gene which co–segregates in one family with presenile dementia and cerebral haemorrhage due to cerebral amyloid angiopathy is reported, suggesting that the clinically distinct entities can be caused by the same mutation.

TL;DR: Dementia and subtypes Alzheimer's disease and vascular dementia may be related to atrial fibrillation even if no clinical stokes have occurred, and the relation with dementia was more pronounced in the relatively younger elderly.

TL;DR: Although the incidence rates of men and women up to age 85 were similar, the lifetime risk of dementia for 55-year-old women was twice as high as for men (0.33 vs. 0.16), reflecting both the higher life expectancy of women and the higher dementia risk at very old age.

TL;DR: An inverse association between blood pressure and dementia risk in elderly persons on antihypertensive medication is suggested, suggesting they may need higher blood pressure levels to maintain an adequate cerebral perfusion or lower blood pressure may be secondary to brain lesions in preclinical stages of dementia.