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Franz X. Bosch

Researcher at Heidelberg University

Publications -  104
Citations -  19398

Franz X. Bosch is an academic researcher from Heidelberg University. The author has contributed to research in topics: Cervical cancer & Cancer. The author has an hindex of 47, co-authored 104 publications receiving 18373 citations.

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Discriminating expression of differentiation markers evolves in transplants of benign and malignant human skin keratinocytes through stromal interactions.

TL;DR: While both proteins and mRNAs were downregulated in benign epithelia, the malignant, invasive tumour cells continuously expressed these non‐epidermal keratins throughout (K19), suprabasally (K4/13) or at invasive sites (K8/18), and the mesenchymal protein vimentin was expressed de novo in invasive areas confronting tumour stroma.
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Differential HPV16 variant distribution in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma.

TL;DR: A non‐random geographical structure of the viral variants distribution is confirmed, which has implications for the implementation of cervical cancer screening algorithms, to ensure proper early detection of elusive ADCs.
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Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majority of head and neck cancers.

TL;DR: It is concluded that only IHC with high sensitivity and the combined expression analysis of mRNAs and proteins is suitable for studying the role of INK4a in HNSCC.
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Estimación de la incidencia de cáncer en España: período 1993–1996

TL;DR: Estimated el numero de neoplasias incidentes en Espana para el periodo 1993-1996, con excepcion del estomago y el cuello de utero y una validacion interna of las estimaciones permite calcular that el error relativo es inferior al 10%.
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Proteomic analysis of field cancerization in pharynx and oesophagus: a prospective pilot study.

TL;DR: Protein profiles of small diagnostic biopsies hold great promise to improve personalized risk assessment in HNSCC and molecular field cancerization had a strong impact on progression‐free survival.