F
Franz X. Bosch
Researcher at Heidelberg University
Publications - 104
Citations - 19398
Franz X. Bosch is an academic researcher from Heidelberg University. The author has contributed to research in topics: Cervical cancer & Cancer. The author has an hindex of 47, co-authored 104 publications receiving 18373 citations.
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Discriminating expression of differentiation markers evolves in transplants of benign and malignant human skin keratinocytes through stromal interactions.
Pascal Tomakidi,Hans-Juergen Stark,Christel Herold-Mende,Franz X. Bosch,Heinrich Steinbauer,Norbert E. Fusenig,Dirk Breitkreutz +6 more
TL;DR: While both proteins and mRNAs were downregulated in benign epithelia, the malignant, invasive tumour cells continuously expressed these non‐epidermal keratins throughout (K19), suprabasally (K4/13) or at invasive sites (K8/18), and the mesenchymal protein vimentin was expressed de novo in invasive areas confronting tumour stroma.
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Differential HPV16 variant distribution in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma.
TL;DR: A non‐random geographical structure of the viral variants distribution is confirmed, which has implications for the implementation of cervical cancer screening algorithms, to ensure proper early detection of elusive ADCs.
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Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majority of head and neck cancers.
Annette Grüttgen,Michaela Reichenzeller,Markus Jünger,Simone Schlien,Annette Affolter,Franz X. Bosch +5 more
TL;DR: It is concluded that only IHC with high sensitivity and the combined expression analysis of mRNAs and proteins is suitable for studying the role of INK4a in HNSCC.
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Estimación de la incidencia de cáncer en España: período 1993–1996
TL;DR: Estimated el numero de neoplasias incidentes en Espana para el periodo 1993-1996, con excepcion del estomago y el cuello de utero y una validacion interna of las estimaciones permite calcular that el error relativo es inferior al 10%.
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Proteomic analysis of field cancerization in pharynx and oesophagus: a prospective pilot study.
M. Roesch-Ely,Alexandra Leipold,Matthias Nees,Dana Holzinger,Andreas Dietz,Christa Flechtenmacher,Thomas Wolf,Marc Zapatka,Franz X. Bosch +8 more
TL;DR: Protein profiles of small diagnostic biopsies hold great promise to improve personalized risk assessment in HNSCC and molecular field cancerization had a strong impact on progression‐free survival.