D
Dana Holzinger
Researcher at German Cancer Research Center
Publications - 45
Citations - 2210
Dana Holzinger is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 21, co-authored 42 publications receiving 1768 citations. Previous affiliations of Dana Holzinger include Heidelberg University & Manchester Royal Infirmary.
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Journal ArticleDOI
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
Xavier Castellsagué,Laia Alemany,Miquel Quer,Gordana Halec,Beatriz Quirós,Sara Tous,Omar Clavero,Llucia Alos,Thorsten Biegner,Tomasz Szafarowski,Maria Alejo,Dana Holzinger,Enrique Cadena,Edith Claros,Gillian Hall,Jan Laco,Mario Poljak,Maria Benevolo,Elena Kasamatsu,Hisham Mehanna,Cathy Ndiaye,Núria Guimerà,Belen Lloveras,Xavier León,Juan C. Ruiz-Cabezas,Isabel Alvarado-Cabrero,Chang Suk Kang,Jin-Kyoung Oh,Marcial Garcia-Rojo,Ermina Iljazovic,Oluseyi F. Ajayi,Flora Duarte,Ashrafun Nessa,Leopoldo Tinoco,Marco A. Duran-Padilla,Edyta C. Pirog,Halina Viarheichyk,Hesler Morales,Valérie Costes,Ana Félix,Maria Julieta V Germar,Marisa Mena,Arzu Ruacan,Asha Jain,Ravi Mehrotra,Marc T. Goodman,Luis Estuardo Lombardi,Annabelle Ferrera,Sani Malami,Estela I. Albanesi,Pablo Dabed,Carla Molina,Rubén López-Revilla,Václav Mandys,Manuel E. González,Julio Velasco,Ignacio G. Bravo,Wim Quint,Michael Pawlita,Nubia Muñoz,Silvia de Sanjosé,F. Xavier Bosch +61 more
TL;DR: This large international study to estimate fractions of head and neck cancers attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation confirms the important role ofHPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
Journal ArticleDOI
The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.
Gunnar Wichmann,Maciej Rosolowski,Knut Krohn,Markus Kreuz,Andreas Boehm,Anett Reiche,Ulrike Scharrer,Dirk Halama,Julia Bertolini,Ulrike Bauer,Dana Holzinger,Michael Pawlita,Jochen Hess,Christoph Engel,Dirk Hasenclever,Markus Scholz,Peter Ahnert,Holger Kirsten,Alexander Hemprich,Christian Wittekind,Olf Herbarth,Friedemann Horn,Andreas Dietz,Markus Loeffler +23 more
TL;DR: It is found that tumors with transcriptionally inactive HPV16 (DNA+ RNA‐) are similar to HPV‐negative (DNA‐) tumors regarding gene expression and frequency of TP53 mutations and that an immune response‐related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status.
Journal ArticleDOI
Viral RNA Patterns and High Viral Load Reliably Define Oropharynx Carcinomas with Active HPV16 Involvement
TL;DR: It is argued that viral load or RNA pattern analysis is better suited than p16(INK4a) expression to identify HPV16-driven tumors in OPSCC patient populations.
Journal ArticleDOI
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas
Efterpi Kostareli,Dana Holzinger,Dana Holzinger,Olga Bogatyrova,Thomas Hielscher,Gunnar Wichmann,Michaela K. Keck,Bernd Lahrmann,Niels Grabe,Christa Flechtenmacher,Christopher R. Schmidt,Tanguy Y. Seiwert,Gerhard Dyckhoff,Andreas Dietz,Daniela Höfler,Michael Pawlita,Axel Benner,Franz X. Bosch,Peter K. Plinkert,Christoph Plass,Dieter Weichenhan,Jochen Hess,Jochen Hess +22 more
TL;DR: This study highlights specific alterations in global gene promoter methylation in HPV-driven OPSCCs and identifies a signature that predicts the clinical outcome inOPSCCs.
Journal ArticleDOI
Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to HPVs 6/11/16/18/31/33/45/52 and 58
Silvia de Sanjosé,Beatriz Serrano,Sara Tous,Maria Alejo,Belen Lloveras,Beatriz Quirós,Omar Clavero,August Vidal,Carla Ferrándiz-Pulido,Miquel Angel Pavon,Dana Holzinger,Gordana Halec,Gordana Halec,Massimo Tommasino,Wim Quint,Michael Pawlita,Nubia Muñoz,Francesc Bosch,Laia Alemany,Vvap Ris Hpv Tt,Neck study groups,Amit Kulkarni +21 more
TL;DR: The authors' estimations suggest a potential impact of the nonavalent HPV vaccine in reducing around 90% of cervical cancer cases and a global reduction of 50% of all the cases at HPV-related cancer sites.