Andreas Dietz

TL;DR: The clinically meaningful prolongation of overall survival and favourable safety profile of pembrolizumab in patients with recurrent or metastatic head and neck squamous cell carcinoma support the further evaluation of p embrolizUMab as a monotherapy and as part of combination therapy in earlier stages of disease.

TL;DR: With accelerated radiotherapy, the efficiency of simultaneously given chemotherapy may be not as high as expected when compared to standard fractionated RT and should be given in radiotherapy regimen only with strong hematologic indication.

TL;DR: Analysis of primary squamous cell carcinomas of the head and neck with respect to the presence of the retinoblastoma tumor suppressor protein, pRb, indicated a strong indication for a human papillomavirus-associated etiology of these tumors and suggested the functional inactivation of the pRB protein by the viral E7 gene product.

TL;DR: An analysis of subsite specific risks showed that heavy smokers carried a nearly ten times higher risk of supraglottic cancer than of glottic cancers and combined alcohol and tobacco consumption showed a synergistic effect.

TL;DR: The data suggest that promoter methylation and subsequent transcript downregulation of SOCs-3 transcripts and, to a much lesser extent, SOCS-1 are involved in the multistep carcinogenesis of HNSCC.