F
Franziska Briest
Researcher at Humboldt University of Berlin
Publications - 5
Citations - 46
Franziska Briest is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: CD34 & DNA repair. The author has an hindex of 3, co-authored 5 publications receiving 13 citations. Previous affiliations of Franziska Briest include Free University of Berlin.
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Journal ArticleDOI
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial.
Kaja Hoyer,R. Hablesreiter,Yoshikage Inoue,Kenichi Yoshida,Franziska Briest,Friederike Christen,Nobuyuki Kakiuchi,Tetsuichi Yoshizato,Yusuke Shiozawa,Yuichi Shiraishi,Jana Käthe Striefler,Sven Bischoff,Philipp Lohneis,Hein Putter,Olga Blau,U. Keilholz,Lars Bullinger,Uwe Pelzer,Michael Hummel,Hanno Riess,Seishi Ogawa,M. Sinn,Frederik Damm,Frederik Damm +23 more
TL;DR: In this article, the authors identified five biologically distinct patient clusters with different actionable lesions and unravelled a previously unappreciated association of SMAD4 alteration status with erlotinib effectiveness.
Journal ArticleDOI
Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment.
Antonia Busse,Liliana H Mochmann,Christiane Spenke,Ruza Arsenic,Franziska Briest,Korinna Jöhrens,Hedwig Lammert,Bence Sipos,Anja A. Kühl,Ralph M. Wirtz,Marianne Pavel,Michael Hummel,Daniel Kaemmerer,Richard P. Baum,Patricia Grabowski +14 more
TL;DR: Investigating the tumor immune microenvironment in NET/NEC with immunohistochemistry and mRNA immunoprofiling found that they lack signs of an activation of an antitumor immune response, but show abundance of several immunosuppressive genes that represent potential targets for immunomodulation.
Journal ArticleDOI
Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Friederike Christen,Raphael Hablesreiter,Kaja Hoyer,Cornelius Hennch,Antje Maluck-Böttcher,Angela Segler,Annett Madadi,Mareike Frick,Mareike Frick,Lars Bullinger,Lars Bullinger,Franziska Briest,Frederik Damm,Frederik Damm +13 more
TL;DR: In this paper, site-specific mutations were introduced in defined regions of DNMT3A, TET2, and ASXL1 in CD34+ progenitor cells that were subsequently analyzed in short-term as well as long-term in vitro culture assays to assess self-renewal and differentiation capacities.
Journal ArticleDOI
Immunohistochemical Study of Mitosis-regulatory Proteins in Gastroenteropancreatic Neuroendocrine Neoplasms.
Franziska Briest,Yawen Wang,Ruza Arsenic,Sefer Elezkurtaj,Erika Berg,Sonja Greshake,Adrian C. Lock,Dieter Hörsch,Christian N. Arnold,Michael Hummel,Britta Siegmund,Patricia Grabowski +11 more
TL;DR: The expression of aurora kinase B is associated with differentiation, progression and the aggressiveness of GEP-NENs, and aurora B is strongly associated with markers of the mitosis regulatory network, survivin, FOXM1 and Ki-67 in the context of tumor progression.
Journal ArticleDOI
Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo.
Franziska Briest,Franziska Briest,Eva J. Koziolek,Jakob Albrecht,Fränze Schmidt,Monique R. Bernsen,Joost C. Haeck,Anja A. Kühl,Dagmar Sedding,Teresa Hartung,Samantha Exner,M. Welzel,Christian Fischer,Carsten Grötzinger,Winfried Brenner,Richard P. Baum,Patricia Grabowski +16 more
TL;DR: It is demonstrated that bortezomib has short-term sensitizing effects when combined with DNA damaging therapy by interfering with DNA repair in vitro and in ovo.