F
Fraser W.H Sutherland
Researcher at Harvard University
Publications - 15
Citations - 2124
Fraser W.H Sutherland is an academic researcher from Harvard University. The author has contributed to research in topics: Mesenchymal stem cell & Progenitor cell. The author has an hindex of 10, co-authored 14 publications receiving 2063 citations. Previous affiliations of Fraser W.H Sutherland include Western Infirmary & Boston Children's Hospital.
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Journal ArticleDOI
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.
Sunjay Kaushal,Gilad E. Amiel,Kristine J. Guleserian,Oz M. Shapira,Tjorvi E. Perry,Fraser W.H Sutherland,Elena Rabkin,Adrian M. Moran,Frederick J. Schoen,Anthony Atala,Shay Soker,Joyce Bischoff,John E. Mayer +12 more
TL;DR: Results indicate that EPCs can function similarly to arterial endothelial cells and thereby confer longer vascular-graft survival and might have other general applications for tissue-engineered structures and in treating vascular diseases.
Journal ArticleDOI
From Stem Cells to Viable Autologous Semilunar Heart Valve
Fraser W.H Sutherland,Fraser W.H Sutherland,Tjorvi E. Perry,Ying Yu,Megan C. Sherwood,Elena Rabkin,Yutaka Masuda,G. Alejandra Garcia,Dawn L. McLellan,George C. Engelmayr,Michael S. Sacks,Frederick J. Schoen,John E. Mayer +12 more
TL;DR: Stem-cell tissue-engineered heart valves can be created from mesenchymal stem cells in combination with a biodegradable scaffold and function satisfactorily in vivo for periods of >4 months, and undergo extensive remodeling in vivo to resemble native heart valves.
Journal ArticleDOI
Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.
Xiao Wu,Elena Rabkin-Aikawa,Kristine J. Guleserian,Tjorvi E. Perry,Yutaka Masuda,Fraser W.H Sutherland,Frederick J. Schoen,John E. Mayer,Joyce Bischoff +8 more
TL;DR: EPC- derived EC can be expanded in vitro and seeded on biodegradable scaffolds with preservation of endothelial phenotype and EPC-derived EC seeded with human smooth muscle cells form microvessels on porous PGA-PLLA scaffolds, indicating that EPC may be well suited for creating microvascular networks within tissue-engineered constructs.
Journal ArticleDOI
A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials.
George C. Engelmayr,Daniel K. Hildebrand,Fraser W.H Sutherland,John E. Mayer,Michael S. Sacks +4 more
TL;DR: A novel bioreactor was developed to study the effect of dynamic flexural stimulation on TEHV biomaterials and indicated that dynamically flexed PGA/PLLA/P4HB scaffolds were approximately 72% and 76% less stiff than static controls.
Journal ArticleDOI
The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue
George C. Engelmayr,Elena Rabkin,Fraser W.H Sutherland,Frederick J. Schoen,John E. Mayer,Michael S. Sacks +5 more
TL;DR: Results show that cyclic flexure can have independent effects onTEHV cell and ECM development, and may be useful in predicting the mechanical properties of TEHV constructed using novel scaffold materials.