Sunjay Kaushal

TL;DR: Results indicate that EPCs can function similarly to arterial endothelial cells and thereby confer longer vascular-graft survival and might have other general applications for tissue-engineered structures and in treating vascular diseases.

TL;DR: The experiments reported here document that the tumor suppressor retinoblastoma protein (pRB) plays an important role in the production and maintenance of the terminally differentiated phenotype of muscle cells, and shows that pRB inactivation, through either phosphorylation, binding to T antigen, or genetic alteration, inhibits myogenesis.

TL;DR: In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.

TL;DR: Muscle enhancer factor-2A induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins.

TL;DR: It is shown that endothelial cells from mature valves can transdifferentiate to a mesenchymal phenotype, and the clonal populations of valvular endothelium cells described here provide a powerful in vitro model for dissecting molecular events that regulate valvules.