F
Fred Bunz
Researcher at Howard Hughes Medical Institute
Publications - 3
Citations - 4331
Fred Bunz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Mitosis & Cohesin. The author has an hindex of 3, co-authored 3 publications receiving 4179 citations.
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Journal ArticleDOI
Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage
Fred Bunz,A. Dutriaux,Christoph Lengauer,Todd Waldman,Shibin Zhou,J. P. Brown,John M. Sedivy,Kenneth W. Kinzler,Bert Vogelstein +8 more
TL;DR: After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle but this arrest could be sustained only when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21.
Journal ArticleDOI
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
Fred Bunz,Paul M. Hwang,Chris Torrance,Chris Torrance,Todd Waldman,Yonggang Zhang,Larry E. Dillehay,Jerry R. Williams,Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein +10 more
TL;DR: It was found that p53 had profound effects on drug responses, and these effects varied dramatically depending on the drug, having significant implications for future efforts to maximize therapeutic efficacy in patients with defined genetic alterations.
Journal ArticleDOI
ArticleSecurin Is Required for Chromosomal Stability in Human Cells
Prasad V. Jallepalli,Irene C. Waizenegger,Fred Bunz,Sabine Langer,Michael R. Speicher,Jan-Michael Peters,Kenneth W. Kinzler,Bert Vogelstein,Christoph Lengauer +8 more
TL;DR: It is shown that human cells without an hSecurin gene lose chromosomes at a high frequency and this loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes.