B
Bert Vogelstein
Researcher at Johns Hopkins University
Publications - 119
Citations - 14278
Bert Vogelstein is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Gene & Gene targeting. The author has an hindex of 20, co-authored 119 publications receiving 14244 citations. Previous affiliations of Bert Vogelstein include Howard Hughes Medical Institute & Yale University.
Papers
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PatentDOI
Serial analysis of gene expression
Kenneth W. Kinzler,Victor Velculescu,Bert Vogelstein,Lin Zhang,ヴェルヴレスク,ヴィクター,イー.,ヴォゲルステイン,バート,キンズラー,ケネス,ダブリュ.,ツァン,リン +7 more
TL;DR: Serial analysis of gene expression (SAGE) should provide a broadly applicable means for the quantitative cataloging and comparison of expressed genes in a variety of normal, developmental, and disease states.
PatentDOI
A simplified system for generating recombinant adenoviruses
TL;DR: In this paper, a recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulations, employing homologous recombination in bacteria rather than in eucaryotic cells.
PatentDOI
Consensus coding sequences of human breast and colorectal cancers
Tobias Sjöblom,Sian Jones,D. Williams Parsons,Laura D. Wood,Jimmy Lin,Thomas D. Barber,Diana Mandelker,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculesu +9 more
TL;DR: In this paper, the authors analyzed 13,023 genes in 11 breast and 11 colorectal cancers and found that individual tumors accumulate an average of 90 mutant genes but only a subset of these contribute to the neoplastic process.
Book
The Genetic Basis of Human Cancer
TL;DR: Part 1 Basic concepts in genetics: genetics, biochemistry and the molecular basis of variant human phenotypes the nature and mechanisms of human gene mutation the Human Genome Project genetic imprinting in cancer.
Journal ArticleDOI
ArticleSecurin Is Required for Chromosomal Stability in Human Cells
Prasad V. Jallepalli,Irene C. Waizenegger,Fred Bunz,Sabine Langer,Michael R. Speicher,Jan-Michael Peters,Kenneth W. Kinzler,Bert Vogelstein,Christoph Lengauer +8 more
TL;DR: It is shown that human cells without an hSecurin gene lose chromosomes at a high frequency and this loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes.