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Fred G. Silva

Researcher at United States and Canadian Academy of Pathology

Publications -  27
Citations -  1879

Fred G. Silva is an academic researcher from United States and Canadian Academy of Pathology. The author has contributed to research in topics: Kidney & Transplantation. The author has an hindex of 20, co-authored 27 publications receiving 1789 citations. Previous affiliations of Fred G. Silva include University of Oklahoma Health Sciences Center & Cedars-Sinai Medical Center.

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The aging kidney

TL;DR: This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in the understanding of the renal aging process.
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Proliferative activity of cyst epithelium in human renal cystic diseases.

TL;DR: The proliferation index (PI) (percentage of PCNA positive cell nuclei among epithelial cells lining the renal cysts) was determined in 10 cases of autosomal dominant polycystic kidney disease (ADPKD), 8 cases of recessive polycysts disease (ARPKD), and8 cases of acquired cystic kidneys disease (ACKD).
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Down-Regulation of Endothelial Expression of Endothelial Cell Protein C Receptor and Thrombomodulin in Coronary Atherosclerosis

TL;DR: The hypothesis that both endothelial cell protein C receptor and thrombomodulin are down-regulated in coronary arteries with atherosclerosis are support the hypothesis that local changes in the anticoagulant properties of the endothelium overlying the plaque contribute to coronary thrombus formation.
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Association of Renal Injury with Increased Oxygen Free Radical Activity and Altered Nitric Oxide Metabolism in Chronic Experimental Hemosiderosis

TL;DR: Findings point to the possible role of ROS in chronic iron overload-induced renal injury, as iron depletion was associated with reduced MDA and tissue nitrotyrosine abundance, increased urinary NOx excretion, normal nitric oxide synthase (NOS) expression, and absence of renal injury.
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Proliferative activity of intrinsic cell populations in the normal human kidney.

TL;DR: Capillary endothelium appears to have the highest proliferation index in the human kidney by these techniques, indicating major variation in the proliferative activity of normal human renal cell populations, along with a significant correlation between PCNA and Ki-67 staining.