Z
Zoltan Laszik
Researcher at University of California, San Francisco
Publications - 104
Citations - 5035
Zoltan Laszik is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Kidney & Pancreas. The author has an hindex of 28, co-authored 100 publications receiving 4503 citations. Previous affiliations of Zoltan Laszik include University of Turku & University of California.
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Journal ArticleDOI
Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis
Saul N. Faust,Michael Levin,Odile B. Harrison,Robert D. Goldin,Marion S. Lockhart,Sheila Kondaveeti,Zoltan Laszik,Charles T. Esmon,Robert S. Heyderman +8 more
TL;DR: In severe meningococcal sepsis, protein C activation is impaired, a finding consistent with down-regulation of the endothelial thrombomodulin-endothelial protein C receptor pathway.
Journal ArticleDOI
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
Fletcher B. Taylor,Deborah J. Stearns-Kurosawa,Shinichiro Kurosawa,Gary L. Ferrell,A. C. K. Chang,Zoltan Laszik,Stanley D. Kosanke,G. Peer,Charles T. Esmon +8 more
TL;DR: It is concluded that protein C/activated protein C binding to EPCR contributes to the negative regulation of the coagulopathic and inflammatory response to E coli and that E PCR provides an additional critical step in the host defense against E coli.
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Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels Implications for the Control of the Protein C Pathway
TL;DR: EPCR may be important in enhancing protein C activation on large vessels and the presence of high levels of EPCR on arterial vessels may help explain why partial protein C deficiency is a weak risk factor for arterial thrombosis.
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Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.
James M. Bates,Haja Mohideen Raffi,Haja Mohideen Raffi,Haja Mohideen Raffi,Krishna Prasadan,Krishna Prasadan,Krishna Prasadan,Ranjan Mascarenhas,Ranjan Mascarenhas,Ranjan Mascarenhas,Zoltan Laszik,Zoltan Laszik,Zoltan Laszik,Nobuyo Maeda,Nobuyo Maeda,Nobuyo Maeda,Scott J. Hultgren,Scott J. Hultgren,Scott J. Hultgren,Satish Kumar +19 more
TL;DR: Findings support the idea that THP serves as a soluble receptor for type 1 fimbriated E. coli and helps eliminate bacteria from the urinary tract.
Journal ArticleDOI
Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc
Tongzhong Ju,Grainger S. Lanneau,Tripti Gautam,Yingchun Wang,Baoyun Xia,Sean R. Stowell,Margaret T. Willard,Wenyi Wang,Jonathan Y. Xia,Rosemary E. Zuna,Zoltan Laszik,Doris M. Benbrook,Marie H. Hanigan,Richard D. Cummings +13 more
TL;DR: Diverse neoplastic lesions, including colon cancer and melanoma-derived cells lines, expressed both Tn and STn antigen due to loss-of-function mutations in Cosmc, the first example of somatic mutations in multiple types of cancers that cause global alterations in cell surface carbohydrate antigen expression.