Fred Gorstein

TL;DR: Data indicate that matrix metalloproteinases are expressed in cell-type, tissue, and reproductive cycle-specific patterns, consistent with regulation by steroid hormones, and with specific roles in the complex tissue growth and remodeling processes occurring in the endometrium during the reproductive cycle.

TL;DR: The expression of the matrilysin gene is regulated in endometrium during the reproductive cycle, implying an important role for matriolysin inendometrial physiologic characteristics.

TL;DR: A review of the microscope slides of the primary tumors for 596 patients with clinical Stage I melanoma revealed that primary lesions displayed two distinct patterns of invasion: single cell invasion with direct extension of the main body of tumor into the reticular dermis or subcutaneous fat, and invasion with "microscope satellites".

TL;DR: The relatively high incidence of both melanoma deaths and regional node metastases for the BANS group merits consideration for testing the efficacy of elective regional node dissection for these patients.

TL;DR: It is estimated that approximately 1500 patients with clinical Stage I melanoma of intermediate thickness in each arm of a randomized clinical trial would be needed to detect an increase in survival rates from elective regional node dissection.