F
Freda Karamalis
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 3
Citations - 2979
Freda Karamalis is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Priming (immunology). The author has an hindex of 3, co-authored 3 publications receiving 2881 citations. Previous affiliations of Freda Karamalis include QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Sally R.M. Bennett,Sally R.M. Bennett,Francis R. Carbone,Freda Karamalis,Freda Karamalis,Richard A. Flavell,Jacques F. A. P. Miller,William R. Heath +7 more
TL;DR: It is shown that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell ‘help’, at least for generation of CTLs by cross-priming, is mediated by signalling throughCD40 onThe antigen- presenting cell.
Journal ArticleDOI
Induction of a CD8( ) cytotoxic T lymphocyte response by cross-priming requires cognate CD4( ) T cell help
Sally R.M. Bennett,Francis R. Carbone,Freda Karamalis,Jacques F. A. P. Miller,William R. Heath +4 more
TL;DR: It is shown that CTL induction by cross-priming with cell-associated ovalbumin requires the active involvement of CD4+ helper T cells, and it is argued that the cognitive nature of this event suggests that theCD4+ T cell actively modifies the APC, converting it into an effective stimulator for the successful priming of the CTL precursor.
Journal Article
Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity.
TL;DR: It is indicated that the duration of priming stimulus and the avidity of the autoreactive CD8+ cells profoundly influence the severity of autoimmune disease.