F
Frederick E. Albrecht
Researcher at Georgetown University Medical Center
Publications - 8
Citations - 405
Frederick E. Albrecht is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Kidney & Dopamine receptor. The author has an hindex of 7, co-authored 8 publications receiving 392 citations.
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Journal ArticleDOI
Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension.
Frederick E. Albrecht,John Drago,Robin A. Felder,Morton P. Printz,G. M. Eisner,Jean E. Robillard,David R. Sibley,Heiner Westphal,Pedro A. Jose +8 more
TL;DR: The cosegregation with hypertension of an impaired D1 receptor regulation of renal sodium transport and the development of elevated systolic and diastolic pressure in mice lacking one or both D1A alleles suggest a causal relationship of the D1 A receptor gene with hypertension.
Journal ArticleDOI
Dopamine1 Receptor, Gsα, and Na+-H+ Exchanger Interactions in the Kidney in Hypertension
TL;DR: It is concluded that the defective D1 receptor function in renal proximal tubules in SHR is proximal to Gs&agr;/effectors and presumably at the receptor level.
Journal ArticleDOI
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.
Frederick E. Albrecht,Jing Xu,Orson W. Moe,Ulrich Hopfer,William F. Simonds,John Orlowski,Pedro A. Jose +6 more
TL;DR: Evidence is provided of a direct regulatory role for G(s)alpha, independent of second messengers, in the D(1)-like-mediated inhibition of NHE3 activity in rat renal BBMV and beta/gamma dimers of heterotrimeric G proteins appear to have a stimulatory effect on NHE2 activity in B BMV.
Journal ArticleDOI
D1 dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats
Xiao Xi Li,Jing Xu,Shaopeng Zheng,Frederick E. Albrecht,Jean E. Robillard,Gilbert M. Eisner,Pedro A. Jose +6 more
TL;DR: The studies indicate that the decreased inhibitory effect of D1-like agonists on NHE3 activity in SHRs (compared with WKY rats) precedes the development of hypertension.
Journal ArticleDOI
Gβ regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development
TL;DR: The decreased inhibitory effect of D(1)-like receptors on NHE activity in BBMV in young rats is caused, in part, by the increased expression and activity of the G protein subunit Gbeta/gamma.