J
Jing Xu
Researcher at Georgetown University
Publications - 10
Citations - 623
Jing Xu is an academic researcher from Georgetown University. The author has contributed to research in topics: Dopamine receptor & Receptor. The author has an hindex of 6, co-authored 10 publications receiving 593 citations. Previous affiliations of Jing Xu include Case Western Reserve University.
Papers
More filters
Journal ArticleDOI
G protein-coupled receptor kinase 4 gene variants in human essential hypertension
Robin A. Felder,Hironobu Sanada,Jing Xu,Pei Ying Yu,Zheng Wang,Hidetsuna Watanabe,Laureano D. Asico,Wei Wang,Shaopeng Zheng,Ikuyo Yamaguchi,Scott M. Williams,James V. Gainer,Nancy J. Brown,Debra J. Hazen-Martin,Lee Jun C. Wong,Jean E. Robillard,Robert M. Carey,Gilbert M. Eisner,Pedro A. Jose +18 more
TL;DR: Findings provide a mechanism for the D1 receptor coupling defect in the kidney and may explain the inability of the kidney to properly excrete sodium in genetic hypertension.
Journal ArticleDOI
Dopamine-1 Receptor Coupling Defect in Renal Proximal Tubule Cells in Hypertension
Hironobu Sanada,Pedro A. Jose,Debra J. Hazen-Martin,Peiying Yu,Jing Xu,David E. Bruns,John Phipps,Robert M. Carey,Robin A. Felder +8 more
TL;DR: The uncoupling of the D1 receptor in both rats (previously described) and humans (described here) suggests that this mechanism may be involved in the pathogenesis of hypertension; the uncoupled may be due to ligand-independent phosphorylation of the C-protein/AC pathway in hypertension.
Journal ArticleDOI
Amelioration of Genetic Hypertension by Suppression of Renal G Protein-Coupled Receptor Kinase Type 4 Expression
Hironobu Sanada,Junichi Yatabe,Sanae Midorikawa,Tetsuo Katoh,Shigeatsu Hashimoto,Tsuyoshi Watanabe,Jing Xu,Yingjin Luo,Xiaoyan Wang,Chunyu Zeng,Ines Armando,Robin A. Felder,Pedro A. Jose +12 more
TL;DR: These studies provide direct evidence of a crucial role of renal GRK4 in the D1 receptor control of sodium excretion and blood pressure in genetic hypertension.
Journal ArticleDOI
Differential expression of adenylyl cyclases in the rat nephron.
Martin J. Bek,Shaopeng Zheng,Jing Xu,Ikuyo Yamaguchi,Laureano D. Asico,Xiao Guang Sun,Pedro A. Jose +6 more
TL;DR: Tissue distribution of adenylyl cyclases along the nephron of Wistar-Kyoto rats is investigated to establish the linkage between receptors and specific AC isoforms and define their functions.
Journal ArticleDOI
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.
Frederick E. Albrecht,Jing Xu,Orson W. Moe,Ulrich Hopfer,William F. Simonds,John Orlowski,Pedro A. Jose +6 more
TL;DR: Evidence is provided of a direct regulatory role for G(s)alpha, independent of second messengers, in the D(1)-like-mediated inhibition of NHE3 activity in rat renal BBMV and beta/gamma dimers of heterotrimeric G proteins appear to have a stimulatory effect on NHE2 activity in B BMV.