Journal ArticleDOI
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.
Frederick E. Albrecht,Jing Xu,Orson W. Moe,Ulrich Hopfer,William F. Simonds,John Orlowski,Pedro A. Jose +6 more
TLDR
Evidence is provided of a direct regulatory role for G(s)alpha, independent of second messengers, in the D(1)-like-mediated inhibition of NHE3 activity in rat renal BBMV and beta/gamma dimers of heterotrimeric G proteins appear to have a stimulatory effect on NHE2 activity in B BMV.Abstract:
NHE3 activity is regulated by phosphorylation/dephosphorylation processes and membrane recycling in intact cells. However, the Na+/H+ exchanger (NHE) can also be regulated by G proteins independent...read more
Citations
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Journal ArticleDOI
Exercise Benefits Brain Function: The Monoamine Connection
Tzu Wei Lin,Yu Min Kuo +1 more
TL;DR: This review focuses on how these three monoamine neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders.
Journal ArticleDOI
Regulatory Binding Partners and Complexes of NHE3
Mark Donowitz,Xuhang Li +1 more
TL;DR: This review deals with short-term regulation of NHE3 and the identity and function of its recognized interacting partners and the multiprotein complexes in which NHE2 functions.
Journal ArticleDOI
Renal Dopamine System: Paracrine Regulator of Sodium Homeostasis and Blood Pressure
TL;DR: In experimental and human hypertension, 2 renal dopaminergic defects have been described: decreased renal generation of dopamine and a D 1 receptor-G protein coupling defect, which lead to renal sodium retention, and each may play an important role in the pathophysiology of essential hypertension.
Journal ArticleDOI
Functional genomics of the dopaminergic system in hypertension
Chunyu Zeng,Hironobu Sanada,Hidetsuna Watanabe,Gilbert M. Eisner,Robin A. Felder,Pedro A. Jose +5 more
TL;DR: The presence of three or more GRK4 variants impairs the natriuretic response to dopaminergic stimulation in humans and in genetically hypertensive rats, renal inhibition ofGRK4 expression ameliorates the hypertension.
Journal ArticleDOI
Perturbation of D1 Dopamine and AT1 Receptor Interaction in Spontaneously Hypertensive Rats
Chunyu Zeng,Yingjin Luo,Laureano D. Asico,Ulrich Hopfer,Gilbert M. Eisner,Robin A. Felder,Pedro A. Jose +6 more
TL;DR: Differential regulation of the expression of D1 and AT1 receptors in RPT cells from WKY and SHR is shown and D1/AT1 receptor interaction are different in R PT cells of W KY andSHR, suggesting an altered interaction of D2 dopamine and AT2 receptors may play a role in the impaired sodium excretion and enhanced vasoconstriction in hypertension.
References
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Journal ArticleDOI
Amiloride and its analogs as tools in the study of ion transport.
TL;DR: The use of amiloride and its analogs in the study of ion transport requires a knowledge of the pharmacology of inhibition of transport proteins, as well as effects on enzymes, receptors, and other cellular processes, such as DNA, RNA, and protein synthesis, and cellular metabolism.
Journal ArticleDOI
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Wei-Jen Tang,Alfred G. Gilman +1 more
TL;DR: G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase, and interactions suggest mechanisms for communication between distinct signal-transducing pathways.
Journal ArticleDOI
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Randy A. Hall,Richard T. Premont,Chung-Wai Chow,Jeremy T. Blitzer,Julie A. Pitcher,Audrey Claing,Robert H. Stoffel,Robert H. Stoffel,Larry S. Barak,Shirish Shenolikar,Edward J. Weinman,Edward J. Weinman,Edward J. Weinman,Sergio Grinstein,Robert J. Lefkowitz +14 more
TL;DR: It is reported here a direct agonist-promoted association of the β2-adrenergic receptor with the Na+/H+ exchanger regulatory factor (NHERF), a protein that regulates the activity of the Na-H- exchanger type 3 (NHE3).
Journal ArticleDOI
Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins
TL;DR: Particular alpha and beta subunit subtypes participate in the signal transduction processes between somatostatin or muscarinic receptors and the voltage-sensitive L-type calcium channel in rat pituitary GH3 cells.
Journal ArticleDOI
Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb
Morimasa Amemiya,Jan Loffing,Marius Lötscher,Brigitte Kaissling,Robert J. Alpern,Orson W. Moe +5 more
TL;DR: NHE-3 is the isoform responsible for NaCl and NaHCO3 absorption in the proximal convoluted tubule, and NahCO absorption in a thick ascending limb and apical membrane Na/H exchange activity is likely mediated by other isoform of the NHE family.