F
Frederik Wein
Researcher at Heidelberg University
Publications - 18
Citations - 2584
Frederik Wein is an academic researcher from Heidelberg University. The author has contributed to research in topics: Mesenchymal stem cell & CD34. The author has an hindex of 14, co-authored 18 publications receiving 2418 citations. Previous affiliations of Frederik Wein include University of St. Gallen & University of Duisburg-Essen.
Papers
More filters
Journal ArticleDOI
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.
Wolfgang Wagner,Frederik Wein,Anja Seckinger,Maria Frankhauser,Ute Wirkner,Ulf Krause,Jonathon Blake,Christian Schwager,Volker Eckstein,Wilhelm Ansorge,Anthony D. Ho +10 more
TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.
Journal ArticleDOI
Cellular origin and pathophysiology of chronic lymphocytic leukemia
Marc Seifert,Ludger Sellmann,Johannes Bloehdorn,Frederik Wein,Stephan Stilgenbauer,Jan Dürig,Ralf Küppers +6 more
TL;DR: Unmutated CLL derives from unmutated mature CD5+ B cells and mutated CLL derived from CD5 +CD27+ post–germinal center B cells.
Journal ArticleDOI
Molecular and Secretory Profiles of Human Mesenchymal Stromal Cells and Their Abilities to Maintain Primitive Hematopoietic Progenitors
Wolfgang Wagner,Christoph Roderburg,Frederik Wein,Anke Diehlmann,Maria Frankhauser,Ralf Schubert,Volker Eckstein,Anthony D. Ho +7 more
TL;DR: The ability to maintain long‐term culture‐initiating cell frequency and a primitive CD34+CD38− immunophenotype was significantly higher for MSC derived from BM and CB compared with those from AT and there was no clear concordance with differences in their potential to maintain primitive function of HPC.
Journal ArticleDOI
The heterogeneity of human mesenchymal stem cell preparations—Evidence from simultaneous analysis of proteomes and transcriptomes
Wolfgang Wagner,Robert E. Feldmann,Robert E. Feldmann,Anja Seckinger,Martin H. Maurer,Frederik Wein,Jonathon Blake,Ulf Krause,Armin Kalenka,Heinrich F. Bürgers,Rainer Saffrich,Patrick Wuchter,Wolfgang Kuschinsky,Anthony D. Ho +13 more
TL;DR: Evidence is provided that homogeneous BM-MSC preparations can reproducibly be isolated under standardized conditions, whereas culture conditions exert a prominent impact on transcriptome, proteome, and cellular organization of BM- MSC.
Journal ArticleDOI
Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells
Thomas Walenda,Simone Bork,Patrick Horn,Frederik Wein,Rainer Saffrich,Anke Diehlmann,Volker Eckstein,Anthony D. Ho,Wolfgang Wagner,Wolfgang Wagner +9 more
TL;DR: MSC support proliferation as well as self‐renewal of HPC with primitive immunophenotype, and the use of early passages of MSC and genetic manipulation of proteins involved in HPC–MSC interaction might further enhance cord blood expansion on MSC.