Jonathon Blake

TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.

TL;DR: The studies indicate that replicative senescence of MSC preparations is a continuous process starting from the first passage onwards, which includes far reaching alterations in phenotype, differentiation potential, global gene expression patterns, and miRNA profiles that need to be considered for therapeutic application of M SC preparations.

TL;DR: The whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma brain tumor from a patient with a germline TP53 mutation is reported, uncovering massive, complex chromosome rearrangements and connecting p53 status and chromothripsis in specific tumor types.

TL;DR: This study demonstrates that ANN analysis reliably identifies biologically relevant miRNAs associated with specific breast cancer phenotypes and indicates that dysregulated miRNA expression could be a marker for poorer prognosis breast cancer, but that it could also present an attractive target for therapeutic intervention.

TL;DR: It was striking that several age-related gene expression changes in both MSC and HPC were also differentially expressed upon replicative senescence of MSC in vitro, indicating that the authors' stem and progenitor cells undergo a similar process also in vivo.