F
Fuxia Li
Researcher at Boston Children's Hospital
Publications - 1
Citations - 15
Fuxia Li is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Endogenous retrovirus & Interferon. The author has co-authored 1 publications.
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WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Ensong Guo,Rourou Xiao,Yifan Wu,Funian Lu,Chen Liu,Bin Yang,Xi Li,Yu Fu,Zizhuo Wang,Yuan Li,Yuhan Huang,Fuxia Li,Xue Wu,Lixin You,Tianyu Qin,Yiling Lu,Xiaoyuan Huang,Ding Ma,Gordon B. Mills,Chaoyang Sun,Gang Chen +20 more
TL;DR: The authors showed that targeting WEE1 up-regulates immune signaling through the double-stranded RNA (dsRNA) viral defense pathway with subsequent responsiveness to immune checkpoint blockade even in cGAS/STING-deficient tumors, which is a typical phenotype across multiple cancer types.