G
G. Deepak Reddy
Publications - 2
Citations - 224
G. Deepak Reddy is an academic researcher. The author has contributed to research in topics: JAK-STAT signaling pathway & Notch signaling pathway. The author has an hindex of 2, co-authored 2 publications receiving 187 citations.
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Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model.
Jaganathan Kowshik,Rajakishore Mishra,Josephraj Sophia,Satabdi Rautray,Kumaraswamy Anbarasu,G. Deepak Reddy,Madhulika Dixit,Sundarasamy Mahalingam,Siddavaram Nagini +8 more
TL;DR: Findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression.
Journal ArticleDOI
Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer
Jaganathan Kowshik,Abdul Basit Baba,Hemant Giri,G. Deepak Reddy,Madhulika Dixit,Siddavaram Nagini +5 more
TL;DR: Evidence is provided that dietary astaxanthin prevents the development and progression of HBP carcinomas through the inhibition of JAK-2/STAT-3 signaling and its downstream events and astaxAnthin that functions as a potent inhibitor of tumour development and progress by targeting JAK/STAT signaling may be an ideal candidate for cancer chemoprevention.