Josephraj Sophia

TL;DR: Findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression.

TL;DR: This review focuses on the intricate interactions between G SKS-3 and oncogenic signalling circuits as well as the feasibility of targeting GSK-3 for the treatment of cancer.

TL;DR: Insight is provided into the molecular mechanisms by which nimbolide augments apoptosis by overcoming the shielding effects of cytoprotective autophagy through modulation of the phosphorylation status of Akt and GSK-3β as well as the ncRNAs miR-126 and HOTAIR.

TL;DR: The present study has unravelled aberrant phosphorylation as a key determinant for oncogenic signalling and acquisition of cancer hallmarks in the HBP model and provided mechanistic insights into the chemotherapeutic potential of nimbolide that may be a useful addition to the armamentarium of natural compounds targeting PI3K for oral cancer treatment.

TL;DR: Blueberry supplementation inhibited the development and progression of HBP carcinomas by abrogating TGF-β and PI3K/Akt pathways and inhibited angiogenesis in ECV304 cells by suppressing migration and tube formation, suggesting that targeting oncogenic signaling pathways that influence acquisition of cancer hallmarks is an effective strategy for chemointervention.