S
Sundarasamy Mahalingam
Researcher at Indian Institute of Technology Madras
Publications - 69
Citations - 2584
Sundarasamy Mahalingam is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Nuclear transport & Cell cycle. The author has an hindex of 24, co-authored 66 publications receiving 2429 citations. Previous affiliations of Sundarasamy Mahalingam include University of Pittsburgh & Institute of Molecular and Cell Biology.
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Journal ArticleDOI
Modulation of amplitude and direction of in vivo immune responses by co‐administration of cytokine gene expression cassettes with DNA immunogens
Jong J. Kim,Neil N. Trivedi,Liesl K. Nottingham,Lake Morrison,Anthony Tsai,Yin Hu,Sundarasamy Mahalingam,Kesen Dang,Lois Ahn,Nicole K. Doyle,Darren M. Wilson,Michael A. Chattergoon,Ara A. Chalian,Jean D. Boyer,Michael G. Agadjanyan,David B. Weiner +15 more
TL;DR: The potential of co‐immunizing using immunologically important molecules together with DNA immunogens as an important tool for the development of more rationally designed vaccines is demonstrated.
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HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.
Velpandi Ayyavoo,Artin Mahboubi,Sundarasamy Mahalingam,R. Ramalingam,R. Ramalingam,Sagar B. Kudchodkar,Williams V. Williams,Douglas R. Green,David B. Weiner +8 more
TL;DR: The finding that Vpr can regulate NF-κB supports the hypothesis that some aspects of viral pathogenesis are the consequence of cell dysregulation by Vpr.
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Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes
Jong J. Kirn,Mark L. Bagarazzi,Neil N. Trivedi,Yin Hu,Ken Kazahaya,Darren M. Wilson,Richard B. Ciccarelli,Michael A. Chattergoon,Kesan Dang,Sundarasamy Mahalingam,Ara A. Chalian,Michael G. Agadjanyan,Jean D. Boyer,Bin Wang,David B. Weiner +14 more
TL;DR: This work has developed expression cassettes for cell surface markers CD80 and CD86, two functionally related costimulatory molecules that play an important role in the induction of T cell-mediated immune responses and observed a dramatic increase in cytotoxic T-lymphocyte induction as well as T-helper cell proliferation after the coadministration of CD86 genes.
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Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
TL;DR: It is observed that substitution mutations in the N-terminal domain of Vpr impaired both nuclear localization and virion packaging, suggesting that the helical structure may play a vital role in modulating both of these biological properties.
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Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model.
Jaganathan Kowshik,Rajakishore Mishra,Josephraj Sophia,Satabdi Rautray,Kumaraswamy Anbarasu,G. Deepak Reddy,Madhulika Dixit,Sundarasamy Mahalingam,Siddavaram Nagini +8 more
TL;DR: Findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression.