Abdul Basit Baba

TL;DR: Astaxanthin targets key molecules in oncogenic signaling pathways and induces apoptosis and is a promising candidate agent for cancer prevention and therapy.

TL;DR: Evidence is provided that dietary astaxanthin prevents the development and progression of HBP carcinomas through the inhibition of JAK-2/STAT-3 signaling and its downstream events and astaxAnthin that functions as a potent inhibitor of tumour development and progress by targeting JAK/STAT signaling may be an ideal candidate for cancer chemoprevention.

TL;DR: It is demonstrated that blueberry abrogates the JAK/STAT-3 pathway and modulates downstream targets that influence cell proliferation and apoptosis in a hamster model of oral oncogenesis, and leads for the development of novel combinations of compounds that can serve as inhibitors of STAT-mediated oncogenic signalling.

TL;DR: A better understanding of the functionally redundant roles of JAKs and STATs may provide a rationale for improving existing cancer therapies which have deleterious effects on normal cells and to identifying novel targets for therapeutic intervention in solid malignancies.

TL;DR: The current review highlights and understands the dual role of TGF-β under different cellular conditions and its crosstalk with other signaling pathways in modulating cell fate.