G
G Meng
Researcher at Harvard University
Publications - 6
Citations - 1102
G Meng is an academic researcher from Harvard University. The author has contributed to research in topics: Duchenne muscular dystrophy & Muscular dystrophy. The author has an hindex of 4, co-authored 6 publications receiving 1072 citations.
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Journal Article
The molecular basis for duchenne versus becker muscular dystrophy: correlation of severity with type of deletion
M. Koenig,Alan H. Beggs,M. Moyer,S. Scherpf,K. Heindrich,T. Bettecken,G Meng,C. R. Müller,M. Lindlöf,H. Kaariainen,A. de la Chapelle,A. Kiuru,M.-L. Savontaus,H. Gilgenkrantz,D. Récan,J. Chelly,Jean-Claude Kaplan,A. E. Covone,N. Archidiacono,Giovanni Romeo,S. Liechti-Gallati,V. Schneider,Suzanne Braga,H. Moser,Basil T. Darras,Patricia E. Murphy,Uta Francke,J. D. Chen,Graeme Morgan,Margaret Denton,Cheryl R. Greenberg,Klaus Wrogemann,L. A. J. Blonden,H.M.B. van Paassen,G.J.B. van Ommen,Louis M. Kunkel +35 more
TL;DR: The distribution and frequency of deletions spanning the entire locus suggests that many "in-frame" deletions of the dystrophin gene are not detected because the individuals bearing them are either asymptomatic or exhibit non-DMD/non-BMD clinical features.
Journal ArticleDOI
On the origin of deletions and point mutations in Duchenne muscular dystrophy: most deletions arise in oogenesis and most point mutations result from events in spermatogenesis.
TL;DR: The results of a study of the rate and origin of mutations in Duchenne muscular dystrophy mean that the vast majority of deletions arise in oogenesis, while most point mutations stem from spermatogenesis.
Journal Article
Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.
TL;DR: A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 times higher than expected, was found with a maximum lod score of 13.50, suggesting a hot spot for recombination within DXS164.
Journal ArticleDOI
Estimate of severe autosomal recessive limb-girdle muscular dystrophy (LGMD2C, LGMD2D) among sporadic muscular dystrophy males: a study of 415 familes.
TL;DR: Based on formal genetics, haplotype analysis, and dystrophin determinations, it is estimated that one in eight sporadic male patients carries autosomal rather than X chromosomal mutations.
HotSpotofRecombination within DXSI64inthe Duchenne Muscular Dystrophy Gene
TL;DR: Thesedata suggest a hotspot forrecombination within DXS164, the intragenic locus of the DMD gene, which spans more than2,000kbp, which has been assigned to band Xp2loftheX chromosome.