K
Klaus Wrogemann
Researcher at University of Manitoba
Publications - 63
Citations - 5013
Klaus Wrogemann is an academic researcher from University of Manitoba. The author has contributed to research in topics: Muscular dystrophy & Limb-girdle muscular dystrophy. The author has an hindex of 31, co-authored 63 publications receiving 4751 citations. Previous affiliations of Klaus Wrogemann include Max Planck Society.
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Journal Article
The molecular basis for duchenne versus becker muscular dystrophy: correlation of severity with type of deletion
M. Koenig,Alan H. Beggs,M. Moyer,S. Scherpf,K. Heindrich,T. Bettecken,G Meng,C. R. Müller,M. Lindlöf,H. Kaariainen,A. de la Chapelle,A. Kiuru,M.-L. Savontaus,H. Gilgenkrantz,D. Récan,J. Chelly,Jean-Claude Kaplan,A. E. Covone,N. Archidiacono,Giovanni Romeo,S. Liechti-Gallati,V. Schneider,Suzanne Braga,H. Moser,Basil T. Darras,Patricia E. Murphy,Uta Francke,J. D. Chen,Graeme Morgan,Margaret Denton,Cheryl R. Greenberg,Klaus Wrogemann,L. A. J. Blonden,H.M.B. van Paassen,G.J.B. van Ommen,Louis M. Kunkel +35 more
TL;DR: The distribution and frequency of deletions spanning the entire locus suggests that many "in-frame" deletions of the dystrophin gene are not detected because the individuals bearing them are either asymptomatic or exhibit non-DMD/non-BMD clinical features.
Journal ArticleDOI
Deep sequencing reveals 50 novel genes for recessive cognitive disorders
Hossein Najmabadi,Hao Hu,Masoud Garshasbi,Tomasz Zemojtel,Seyedeh Sedigheh Abedini,Wei Chen,Masoumeh Hosseini,Farkhondeh Behjati,Stefan A. Haas,Payman Jamali,Agnes Zecha,Marzieh Mohseni,Lucia Püttmann,Leyla Nouri Vahid,C Jensen,Lia Abbasi Moheb,M Bienek,Farzaneh Larti,Ines Mueller,Robert Weissmann,Hossein Darvish,Klaus Wrogemann,Klaus Wrogemann,Valeh Hadavi,Bettina Lipkowitz,Sahar Esmaeeli-Nieh,Dagmar Wieczorek,Roxana Kariminejad,Saghar Ghasemi Firouzabadi,Monika Cohen,Zohreh Fattahi,Imma Rost,Faezeh Mojahedi,Christoph Hertzberg,Atefeh Dehghan,Anna Rajab,Mohammad Javad Soltani Banavandi,Julia Hoffer,Masoumeh Falah,Luciana Musante,Vera M. Kalscheuer,Reinhard Ullmann,Andreas W. Kuss,Andreas Tzschach,Kimia Kahrizi,Hans-Hilger Ropers +45 more
TL;DR: This study, the largest published so far, has revealed additional mutations in 23 genes previously implicated in intellectual disability or related neurological disorders, as well as single, probably disease-causing variants in 50 novel candidate genes.
Journal ArticleDOI
Prenatal diagnosis and carrier detection of Duchenne muscular dystrophy with closely linked RFLPs.
Egbert Bakker,N. Goor,Klaus Wrogemann,Louis M. Kunkel,W.A Fenton,Danielle Majoor-Krakauer,M.G.J Jahoda,G.J.B. van Ommen,Marten H. Hofker,Jean-Louis Mandel,Kay E. Davies,Huntington F. Willard,L. A. Sandkuyl,Anthonie J. van Essen,E.S Sachs,Peter L. Pearson +15 more
TL;DR: By the use of a series of closely linked DNA probes detecting restriction fragment length polymorphisms (RFLPs), a double crossover was detected in a Duchenne muscular dystrophy carrier and an affected male fetus was diagnosed at 12 weeks of gestation.
Journal ArticleDOI
Limb-Girdle Muscular Dystrophy Type 2H Associated with Mutation in TRIM32, a Putative E3-Ubiquitin–Ligase Gene
Patrick Frosk,Tracey Weiler,Edward Nylen,Thangirala Sudha,Cheryl R. Greenberg,Kenneth Morgan,T. Mary Fujiwara,Klaus Wrogemann +7 more
TL;DR: The mutation in the tripartite-motif-containing gene (TRIM32) that replaces aspartate with asparagine at position 487 appears to be the causative mutation of LGMD2H, which represents a new pathogenic mechanism leading to muscular dystrophy.
Journal ArticleDOI
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
Hao Hu,Stefan A. Haas,Jamel Chelly,Jamel Chelly,H Van Esch,Martine Raynaud,A.P.M. de Brouwer,Stefanie Weinert,Guy Froyen,Suzanna G.M. Frints,Frédéric Laumonnier,Tomasz Zemojtel,Michael I. Love,Hugues Richard,Anne-Katrin Emde,M Bienek,C Jensen,Melanie Hambrock,Utz Fischer,Claudia Langnick,Mirjam Feldkamp,Willemijn M. Wissink-Lindhout,Nicolas Lebrun,Nicolas Lebrun,L. Castelnau,L. Castelnau,Julien Rucci,Julien Rucci,R. Montjean,R. Montjean,Olivier Dorseuil,Olivier Dorseuil,Pierre Billuart,Pierre Billuart,T. Stuhlmann,Marie Shaw,Mark A. Corbett,Alison Gardner,Saffron A.G. Willis-Owen,Saffron A.G. Willis-Owen,C Tan,Kathryn Friend,Stefanie Belet,K. E. P. van Roozendaal,M Jimenez-Pocquet,Marie-Pierre Moizard,Nathalie Ronce,Ruping Sun,Sean O'Keeffe,Ramu Chenna,A. van Bömmel,Jonathan Göke,Anna Hackett,Michael Field,Louise Christie,Jackie Boyle,Eric Haan,Eric Haan,John Nelson,Gillian Turner,Gareth Baynam,Gabriele Gillessen-Kaesbach,Ulrich Müller,Daniela Steinberger,Bartłomiej Budny,Magdalena Badura-Stronka,Anna Latos-Bielenska,Lilian Bomme Ousager,Peter Wieacker,G. Rodríguez Criado,Marie-Louise Bondeson,Göran Annerén,Andreas Dufke,Monika Cohen,L. Van Maldergem,Catherine Vincent-Delorme,Bernard Echenne,B. Simon-Bouy,Tjitske Kleefstra,Marjolein H. Willemsen,J. P. Fryns,Koenraad Devriendt,Reinhard Ullmann,Martin Vingron,Klaus Wrogemann,Klaus Wrogemann,Thomas F. Wienker,Andreas Tzschach,H Van Bokhoven,Jozef Gecz,Thomas J. Jentsch,Wei Chen,Hans-Hilger Ropers,Vera M. Kalscheuer +93 more
TL;DR: It is suggested that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic evidence for X- Chromosome locus involvement may resolve up to 58% of Fragile X-negative cases.